Supplement stacks / Buspirone + St Johns Wort
Can You Take Buspirone with St Johns Wort?
Buspirone is an anxiolytic medication that may interact with St. John's Wort, a herbal supplement often used for depression and anxiety. St. John's Wort can induce cytochrome P450 enzymes, potentially affecting the metabolism of buspirone, leading to altered drug levels. Iron supplementation does not have a direct interaction with either buspirone or St. John's Wort but should be monitored for absorption issues. Caution is advised when combining these substances.
Conservative, AI-assisted reading of publicly available medical sources (NIH, Mayo Clinic, WebMD, Examine.com). Informational only — it can't account for your medications, conditions, or genetics.
St. John's Wort may reduce the effectiveness of buspirone by increasing its metabolism.
Generally well-tolerated; may cause dizziness or drowsiness.
Typical dosage: 15-60 mg daily, divided into doses.
- Dizziness
- Nausea
- Headache
- Avoid combining with St. John's Wort without medical supervision; monitor for increased side effects.
Generally safe for short-term use; may cause photosensitivity and gastrointestinal upset.
Typical dosage: 300-900 mg daily, divided into doses.
- Gastrointestinal upset
- Fatigue
- Photosensitivity
- May interact with buspirone; consult healthcare provider before use.
- Monitor for increased side effects of buspirone.
These come up in questions about this combination — they are not part of the pair above.
Iron
Safe when taken as directed; excessive intake can lead to toxicity.
Typical dosage: 8-18 mg daily, depending on age and gender.
- Constipation
- Nausea
- Stomach upset
- Take iron supplements separately from other medications to avoid absorption issues; ideally 2 hours apart.
St. John's Wort can be taken in the morning or evening, while buspirone should be taken consistently at the same times each day for optimal results.
- Consult with a healthcare provider before combining St. John's Wort with buspirone.
- Consider monitoring mood and anxiety levels closely if combining these substances.
- Take iron supplements at least 2 hours apart from buspirone to avoid absorption issues.
Can you take Buspirone and St Johns Wort together?
Buspirone is an anxiolytic medication that may interact with St. John's Wort, a herbal supplement often used for depression and anxiety. St. John's Wort can induce cytochrome P450 enzymes, potentially affecting the metabolism of buspirone, leading to altered drug levels. Iron supplementation does not have a direct interaction with either buspirone or St. John's Wort but should be monitored for absorption issues. Caution is advised when combining these substances.
How safe is the Buspirone and St Johns Wort combination?
Our analysis of publicly available medical sources scores this combination 5/10 (medium risk). This is an informational estimate, not medical advice — always confirm with a healthcare professional.
When should you take Buspirone and St Johns Wort?
St. John's Wort can be taken in the morning or evening, while buspirone should be taken consistently at the same times each day for optimal results.
What should you watch out for when combining Buspirone and St Johns Wort?
Take iron supplements at least 2 hours apart from buspirone to avoid absorption issues.
Taking more than these two? Run your complete supplement list — plus any medications — through the live checker for a combined analysis.
Analyze my stackGenetics change how you process supplements like these. Upload raw 23andMe or Ancestry data for a personalized supplement report.
See the DNA reportNot medical advice
Analysis generated August 11, 2026 · Sources include NIH, Mayo Clinic, WebMD, and Examine.com · How our analysis works