Supplement stacks / Lamotrigine + St Johns Wort
Can You Take Lamotrigine with St Johns Wort?
Taking St. John's Wort with Lamotrigine may lead to reduced effectiveness of Lamotrigine due to St. John's Wort's induction of certain liver enzymes. Caution is advised, and consultation with a healthcare provider is essential before combining these substances.
Conservative, AI-assisted reading of publicly available medical sources (NIH, Mayo Clinic, WebMD, Examine.com). Informational only — it can't account for your medications, conditions, or genetics.
St. John's Wort may decrease the plasma concentration of Lamotrigine, potentially leading to reduced therapeutic effects.
Generally well-tolerated; however, it can cause serious skin rashes and other side effects.
Typical dosage: 100-400 mg daily, depending on the condition being treated.
- Dizziness
- Headache
- Nausea
- Rash
- Monitor for skin reactions; consult healthcare provider if rash develops.
- Adjust dosage carefully when combined with other medications.
Generally considered safe for short-term use; however, it can interact with various medications.
Typical dosage: 300-900 mg daily, divided into doses.
- Gastrointestinal upset
- Fatigue
- Allergic skin reactions
- May reduce the effectiveness of Lamotrigine; consult healthcare provider before use.
- Avoid use if pregnant or nursing.
St. John's Wort can be taken in the morning; however, if combined with Lamotrigine, it is advisable to separate doses by at least 4 hours.
- Consult with a healthcare provider before starting St. John's Wort while on Lamotrigine.
- Consider alternative treatments for mood support that do not interact with Lamotrigine.
- Monitor for decreased effectiveness of Lamotrigine if St. John's Wort is taken concurrently.
Can you take Lamotrigine and St Johns Wort together?
Taking St. John's Wort with Lamotrigine may lead to reduced effectiveness of Lamotrigine due to St. John's Wort's induction of certain liver enzymes. Caution is advised, and consultation with a healthcare provider is essential before combining these substances.
How safe is the Lamotrigine and St Johns Wort combination?
Our analysis of publicly available medical sources scores this combination 4/10 (high risk). This is an informational estimate, not medical advice — always confirm with a healthcare professional.
When should you take Lamotrigine and St Johns Wort?
St. John's Wort can be taken in the morning; however, if combined with Lamotrigine, it is advisable to separate doses by at least 4 hours.
What should you watch out for when combining Lamotrigine and St Johns Wort?
Monitor for decreased effectiveness of Lamotrigine if St. John's Wort is taken concurrently.
Taking more than these two? Run your complete supplement list — plus any medications — through the live checker for a combined analysis.
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Analysis generated August 11, 2026 · Sources include NIH, Mayo Clinic, WebMD, and Examine.com · How our analysis works