Supplement stacks / Lamotrigine + St Johns Wort
Can You Take Lamotrigine with St Johns Wort?
Lamotrigine and St Johns Wort: one interaction flagged, scored 4/10 (high risk). The count and score come from an AI-written analysis checked against our interaction rules, which can only make it stricter. Not medical advice.
Safety at a glance
This score comes from an AI-written analysis of the pair. Our interaction rules check it and can only make it stricter, never milder. Informational only: it can't account for your medications, conditions, or genetics.
What the AI-written analysis says
Taking St. John's Wort with Lamotrigine may lead to reduced effectiveness of Lamotrigine due to St. John's Wort's induction of certain liver enzymes. Caution is advised, and consultation with a healthcare provider is essential before combining these substances.
Lamotrigine is a prescription medication. This page describes publicly documented interactions — it can't see your dose, your other prescriptions, or your labs. Discuss any supplement with the prescriber or pharmacist who manages this medication before combining.
Known interactions
St. John's Wort may decrease the plasma concentration of Lamotrigine, potentially leading to reduced therapeutic effects.
Lamotrigine
From the AI-written analysis.
Generally well-tolerated; however, it can cause serious skin rashes and other side effects.
Typical dosage: As prescribed or as directed on the label
- Dizziness
- Headache
- Nausea
- Rash
- Monitor for skin reactions; consult healthcare provider if rash develops.
- Adjust dosage carefully when combined with other medications.
St. John's Wort
From the AI-written analysis.
Generally considered safe for short-term use; however, it can interact with various medications.
Typical dosage: 300-900 mg daily, divided into doses.
- Gastrointestinal upset
- Fatigue
- Allergic skin reactions
- May reduce the effectiveness of Lamotrigine; consult healthcare provider before use.
- Avoid use if pregnant or nursing.
Timing
Take as prescribed — we do not schedule prescription medications. Follow the label or your prescriber, and ask your pharmacist before changing when you take it.
Recommendations
- Consult with a healthcare provider before starting St. John's Wort while on Lamotrigine.
- Consider alternative treatments for mood support that do not interact with Lamotrigine.
Watch out for
- Monitor for decreased effectiveness of Lamotrigine if St. John's Wort is taken concurrently.
Frequently asked questions
Can you take Lamotrigine and St Johns Wort together?
Lamotrigine and St Johns Wort: one interaction flagged, scored 4/10 (high risk). The count and score come from an AI-written analysis checked against our interaction rules, which can only make it stricter. Not medical advice.
What score does the Lamotrigine and St Johns Wort combination get?
The Lamotrigine and St Johns Wort combination is scored 4/10 (high risk). The score comes from an AI-written analysis checked against our interaction rules, which can only make it stricter. Not medical advice. Always confirm with a healthcare professional.
When should you take Lamotrigine and St Johns Wort?
Take as prescribed — we do not schedule prescription medications. Follow the label or your prescriber, and ask your pharmacist before changing when you take it.
What should you watch out for when combining Lamotrigine and St Johns Wort?
Monitor for decreased effectiveness of Lamotrigine if St. John's Wort is taken concurrently.
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Not medical advice
AI-written analysis generated August 11, 2026, checked by our interaction rules · How our analysis works