Supplement stacks / Diltiazem + St Johns Wort

Can You Take Diltiazem with St Johns Wort?

St. John's Wort may interact with diltiazem, potentially affecting its efficacy due to enzyme induction. Caution is advised, and consultation with a healthcare provider is essential before combining these substances.

Safety at a glance
Medium risk
Safety score4/10

Conservative, AI-assisted reading of publicly available medical sources (NIH, Mayo Clinic, WebMD, Examine.com). Informational only — it can't account for your medications, conditions, or genetics.

Known interactions
medium

Suggestion: Consult healthcare provider before use.

Diltiazem

Generally well-tolerated; monitor for side effects, especially in combination with other medications.

Typical dosage: 30-120 mg daily, depending on formulation

Common side effects:
  • Dizziness
  • Headache
  • Edema
Warnings:
  • Monitor blood pressure and heart rate; consult healthcare provider for any unusual symptoms.
St. John's Wort

Generally safe for most individuals; however, it can interact with various medications.

Typical dosage: 300-900 mg daily, divided into doses

Common side effects:
  • Gastrointestinal upset
  • Fatigue
  • Allergic skin reactions
Warnings:
  • May reduce the effectiveness of certain medications, including diltiazem; consult healthcare provider before use.
Timing

If approved by a healthcare provider, take St. John's Wort and diltiazem at least 4 hours apart to minimize interaction risk.

Recommendations
  • Avoid combining St. John's Wort with diltiazem without medical supervision.
Watch out for
  • Consult healthcare provider before starting St. John's Wort while on diltiazem.
Frequently asked questions

Can you take Diltiazem and St Johns Wort together?

St. John's Wort may interact with diltiazem, potentially affecting its efficacy due to enzyme induction. Caution is advised, and consultation with a healthcare provider is essential before combining these substances.

How safe is the Diltiazem and St Johns Wort combination?

Our analysis of publicly available medical sources scores this combination 4/10 (medium risk). This is an informational estimate, not medical advice — always confirm with a healthcare professional.

When should you take Diltiazem and St Johns Wort?

If approved by a healthcare provider, take St. John's Wort and diltiazem at least 4 hours apart to minimize interaction risk.

What should you watch out for when combining Diltiazem and St Johns Wort?

Consult healthcare provider before starting St. John's Wort while on diltiazem.

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Analysis generated August 11, 2026 · Sources include NIH, Mayo Clinic, WebMD, and Examine.com · How our analysis works