Supplement stacks / Bupropion + St Johns Wort
Can You Take Bupropion with St Johns Wort?
Combining bupropion with St. John's Wort may lead to reduced effectiveness of bupropion and potential side effects. Both substances have limited evidence regarding their interactions, and caution is advised. Consultation with a healthcare provider is essential before combining these.
Conservative, AI-assisted reading of publicly available medical sources (NIH, Mayo Clinic, WebMD, Examine.com). Informational only — it can't account for your medications, conditions, or genetics.
Suggestion: Consult healthcare provider before use.
Generally well-tolerated; risk of seizures at high doses.
Typical dosage: 150-400 mg daily
- insomnia
- dry mouth
- dizziness
- Monitor for increased seizure risk, especially in predisposed individuals.
Generally safe but can cause photosensitivity and gastrointestinal upset.
Typical dosage: 300-900 mg daily (standardized extract)
- dry mouth
- dizziness
- fatigue
- May interact with various medications; consult healthcare provider.
If advised to take both, space them out by at least 4 hours to minimize interaction risk.
- Avoid combining St. John's Wort with bupropion without medical supervision.
- Monitor for changes in mood or seizure activity if combining these substances.
Can you take Bupropion and St Johns Wort together?
Combining bupropion with St. John's Wort may lead to reduced effectiveness of bupropion and potential side effects. Both substances have limited evidence regarding their interactions, and caution is advised. Consultation with a healthcare provider is essential before combining these.
How safe is the Bupropion and St Johns Wort combination?
Our analysis of publicly available medical sources scores this combination 4/10 (medium risk). This is an informational estimate, not medical advice — always confirm with a healthcare professional.
When should you take Bupropion and St Johns Wort?
If advised to take both, space them out by at least 4 hours to minimize interaction risk.
What should you watch out for when combining Bupropion and St Johns Wort?
Monitor for changes in mood or seizure activity if combining these substances.
Taking more than these two? Run your complete supplement list — plus any medications — through the live checker for a combined analysis.
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Analysis generated August 11, 2026 · Sources include NIH, Mayo Clinic, WebMD, and Examine.com · How our analysis works