Supplement stacks / Bupropion + St Johns Wort
Can You Take Bupropion with St Johns Wort?
Bupropion and St Johns Wort: one interaction flagged, scored 4/10 (medium risk). The count and score come from an AI-written analysis checked against our interaction rules, which can only make it stricter. Not medical advice.
Safety at a glance
This score comes from an AI-written analysis of the pair. Our interaction rules check it and can only make it stricter, never milder. Informational only: it can't account for your medications, conditions, or genetics.
What the AI-written analysis says
Combining bupropion with St. John's Wort may lead to reduced effectiveness of bupropion and potential side effects. Both substances have limited evidence regarding their interactions, and caution is advised. Consultation with a healthcare provider is essential before combining these.
Bupropion is a prescription medication. This page describes publicly documented interactions — it can't see your dose, your other prescriptions, or your labs. Discuss any supplement with the prescriber or pharmacist who manages this medication before combining.
Known interactions
Suggestion: Consult healthcare provider before use.
Bupropion
From the AI-written analysis.
Generally well-tolerated; risk of seizures at high doses.
Typical dosage: As prescribed or as directed on the label
- insomnia
- dry mouth
- dizziness
- Monitor for increased seizure risk, especially in predisposed individuals.
St John's Wort
From the AI-written analysis.
Generally safe but can cause photosensitivity and gastrointestinal upset.
Typical dosage: 300-900 mg daily (standardized extract)
- dry mouth
- dizziness
- fatigue
- May interact with various medications; consult healthcare provider.
Timing
If advised to take both, space them out by at least 4 hours to minimize interaction risk.
Recommendations
- Avoid combining St. John's Wort with bupropion without medical supervision.
Watch out for
- Monitor for changes in mood or seizure activity if combining these substances.
Frequently asked questions
Can you take Bupropion and St Johns Wort together?
Bupropion and St Johns Wort: one interaction flagged, scored 4/10 (medium risk). The count and score come from an AI-written analysis checked against our interaction rules, which can only make it stricter. Not medical advice.
What score does the Bupropion and St Johns Wort combination get?
The Bupropion and St Johns Wort combination is scored 4/10 (medium risk). The score comes from an AI-written analysis checked against our interaction rules, which can only make it stricter. Not medical advice. Always confirm with a healthcare professional.
When should you take Bupropion and St Johns Wort?
If advised to take both, space them out by at least 4 hours to minimize interaction risk.
What should you watch out for when combining Bupropion and St Johns Wort?
Monitor for changes in mood or seizure activity if combining these substances.
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Not medical advice
AI-written analysis generated August 11, 2026, checked by our interaction rules · How our analysis works