Supplement stacks / St Johns Wort + Sumatriptan
Can You Take St Johns Wort with Sumatriptan?
St Johns Wort and Sumatriptan: one interaction flagged, scored 3/10 (high risk). The count and score come from an AI-written analysis checked against our interaction rules, which can only make it stricter. Not medical advice.
Safety at a glance
This score comes from an AI-written analysis of the pair. Our interaction rules check it and can only make it stricter, never milder. Informational only: it can't account for your medications, conditions, or genetics.
What the AI-written analysis says
St. John's Wort may interact with sumatriptan, potentially affecting its efficacy and safety. Caution is advised when considering this combination, and consultation with a healthcare provider is essential.
Sumatriptan is a prescription medication. This page describes publicly documented interactions — it can't see your dose, your other prescriptions, or your labs. Discuss any supplement with the prescriber or pharmacist who manages this medication before combining.
Known interactions
St. John's Wort may reduce the effectiveness of sumatriptan due to its effects on liver enzymes.
St. John's Wort
From the AI-written analysis.
Generally considered safe for short-term use; however, it can cause photosensitivity and may interact with various medications.
Typical dosage: 300-900 mg daily, divided into doses
- Gastrointestinal upset
- Fatigue
- Dry mouth
- Dizziness
- May interact with antidepressants, anticoagulants, and other medications; consult healthcare provider before use.
Sumatriptan
From the AI-written analysis.
Generally safe when used as directed; may cause side effects such as dizziness and nausea.
Typical dosage: As prescribed or as directed on the label
- Dizziness
- Nausea
- Fatigue
- Chest tightness
- Use with caution in patients with cardiovascular disease; consult healthcare provider for any concerns.
Timing
No timing arrangement makes this combination safe — see the warnings above.
Recommendations
- Consult with a healthcare provider before combining St. John's Wort with sumatriptan.
- Consider alternative treatments for mood support that do not interact with sumatriptan.
Watch out for
- Combining two or more serotonergic substances can raise the risk of serotonin syndrome, a potentially serious reaction. Do not combine them without medical supervision, and seek care for agitation, confusion, tremor, sweating, rapid heartbeat, or high fever.
- No timing arrangement makes this combination safe — see the warnings above.
Frequently asked questions
Can you take St Johns Wort and Sumatriptan together?
St Johns Wort and Sumatriptan: one interaction flagged, scored 3/10 (high risk). The count and score come from an AI-written analysis checked against our interaction rules, which can only make it stricter. Not medical advice.
What score does the St Johns Wort and Sumatriptan combination get?
The St Johns Wort and Sumatriptan combination is scored 3/10 (high risk). The score comes from an AI-written analysis checked against our interaction rules, which can only make it stricter. Not medical advice. Always confirm with a healthcare professional.
When should you take St Johns Wort and Sumatriptan?
No timing arrangement makes this combination safe — see the warnings above.
What should you watch out for when combining St Johns Wort and Sumatriptan?
Combining two or more serotonergic substances can raise the risk of serotonin syndrome, a potentially serious reaction. Do not combine them without medical supervision, and seek care for agitation, confusion, tremor, sweating, rapid heartbeat, or high fever. No timing arrangement makes this combination safe — see the warnings above.
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Not medical advice
AI-written analysis generated August 11, 2026, checked by our interaction rules · How our analysis works