Supplement stacks / St Johns Wort + Sumatriptan
Can You Take St Johns Wort with Sumatriptan?
St. John's Wort may interact with sumatriptan, potentially affecting its efficacy and safety. Caution is advised when considering this combination, and consultation with a healthcare provider is essential.
Conservative, AI-assisted reading of publicly available medical sources (NIH, Mayo Clinic, WebMD, Examine.com). Informational only — it can't account for your medications, conditions, or genetics.
St. John's Wort may reduce the effectiveness of sumatriptan due to its effects on liver enzymes.
Generally considered safe for short-term use; however, it can cause photosensitivity and may interact with various medications.
Typical dosage: 300-900 mg daily, divided into doses
- Gastrointestinal upset
- Fatigue
- Dry mouth
- Dizziness
- May interact with antidepressants, anticoagulants, and other medications; consult healthcare provider before use.
Generally safe when used as directed; may cause side effects such as dizziness and nausea.
Typical dosage: 25-100 mg as needed, not exceeding 200 mg in 24 hours
- Dizziness
- Nausea
- Fatigue
- Chest tightness
- Use with caution in patients with cardiovascular disease; consult healthcare provider for any concerns.
If both are to be taken, consider taking sumatriptan at the onset of migraine symptoms and St. John's Wort at a different time of day to minimize interaction risk.
- Consult with a healthcare provider before combining St. John's Wort with sumatriptan.
- Consider alternative treatments for mood support that do not interact with sumatriptan.
- Combining two or more serotonergic substances can raise the risk of serotonin syndrome, a potentially serious reaction. Do not combine them without medical supervision, and seek care for agitation, confusion, tremor, sweating, rapid heartbeat, or high fever.
- Monitor for reduced efficacy of sumatriptan if St. John's Wort is taken concurrently; consider spacing them apart by at least 4 hours.
Can you take St Johns Wort and Sumatriptan together?
St. John's Wort may interact with sumatriptan, potentially affecting its efficacy and safety. Caution is advised when considering this combination, and consultation with a healthcare provider is essential.
How safe is the St Johns Wort and Sumatriptan combination?
Our analysis of publicly available medical sources scores this combination 3/10 (high risk). This is an informational estimate, not medical advice — always confirm with a healthcare professional.
When should you take St Johns Wort and Sumatriptan?
If both are to be taken, consider taking sumatriptan at the onset of migraine symptoms and St. John's Wort at a different time of day to minimize interaction risk.
What should you watch out for when combining St Johns Wort and Sumatriptan?
Combining two or more serotonergic substances can raise the risk of serotonin syndrome, a potentially serious reaction. Do not combine them without medical supervision, and seek care for agitation, confusion, tremor, sweating, rapid heartbeat, or high fever. Monitor for reduced efficacy of sumatriptan if St. John's Wort is taken concurrently; consider spacing them apart by at least 4 hours.
Taking more than these two? Run your complete supplement list — plus any medications — through the live checker for a combined analysis.
Analyze my stackGenetics change how you process supplements like these. Upload raw 23andMe or Ancestry data for a personalized supplement report.
See the DNA reportNot medical advice
Analysis generated August 11, 2026 · Sources include NIH, Mayo Clinic, WebMD, and Examine.com · How our analysis works