Supplement stacks / Mirtazapine + St Johns Wort
Can You Take Mirtazapine with St Johns Wort?
Mirtazapine and St Johns Wort: one interaction flagged, scored 3/10 (high risk). The count and score come from an AI-written analysis checked against our interaction rules, which can only make it stricter. Not medical advice.
Safety at a glance
This score comes from an AI-written analysis of the pair. Our interaction rules check it and can only make it stricter, never milder. Informational only: it can't account for your medications, conditions, or genetics.
What the AI-written analysis says
Combining St. John's Wort with mirtazapine may lead to reduced effectiveness of mirtazapine due to St. John's Wort's induction of certain liver enzymes. This combination could potentially increase the risk of side effects or reduce therapeutic effects. Caution is advised, and consultation with a healthcare provider is essential.
Mirtazapine is a prescription medication. This page describes publicly documented interactions — it can't see your dose, your other prescriptions, or your labs. Discuss any supplement with the prescriber or pharmacist who manages this medication before combining.
Known interactions
Mirtazapine
From the AI-written analysis.
Generally well-tolerated; however, it can cause sedation and weight gain.
Typical dosage: As prescribed or as directed on the label
- Drowsiness
- Increased appetite
- Dry mouth
- Monitor for increased sedation or side effects when combined with other sedatives.
St. John's Wort
From the AI-written analysis.
Generally considered safe for short-term use; however, it can interact with various medications.
Typical dosage: 300-900 mg daily, divided into doses
- Gastrointestinal upset
- Fatigue
- Allergic skin reactions
- May interact with antidepressants, including mirtazapine; consult healthcare provider before use.
Also commonly mentioned
These come up in questions about this combination. They are not part of the pair above. From the AI-written analysis.
Omega-3 Fatty Acids
Generally safe; may support mood and cognitive function.
Typical dosage: 1000-3000 mg daily
- Fishy aftertaste
- Gastrointestinal discomfort
- Consult healthcare provider if on anticoagulants.
L-Theanine
Considered safe; may promote relaxation without sedation.
Typical dosage: 100-400 mg daily
- Headache
- Dizziness
- Consult healthcare provider if taking other medications affecting mood.
Vitamin D3
Generally safe; important for overall health and mood regulation.
Typical dosage: 600-2000 IU daily
- Nausea
- Constipation
- Monitor levels if taking high doses; consult healthcare provider.
Timing
St. John's Wort should be taken consistently at the same time each day to maintain stable levels in the body. No timing arrangement makes this combination safe — see the warnings above.
Watch out for
- Combining two or more serotonergic substances can raise the risk of serotonin syndrome, a potentially serious reaction. Ask a pharmacist, or the prescriber if any of these was prescribed, before you combine them. If any of these is a prescription, do not stop or change it on your own. Seek care for agitation, confusion, tremor, sweating, rapid heartbeat, or high fever.
- Avoid combining St. John's Wort with mirtazapine without consulting a healthcare provider due to potential interactions.
Frequently asked questions
Can you take Mirtazapine and St Johns Wort together?
Mirtazapine and St Johns Wort: one interaction flagged, scored 3/10 (high risk). The count and score come from an AI-written analysis checked against our interaction rules, which can only make it stricter. Not medical advice.
What score does the Mirtazapine and St Johns Wort combination get?
The Mirtazapine and St Johns Wort combination is scored 3/10 (high risk). The score comes from an AI-written analysis checked against our interaction rules, which can only make it stricter. Not medical advice. Always confirm with a healthcare professional.
When should you take Mirtazapine and St Johns Wort?
St. John's Wort should be taken consistently at the same time each day to maintain stable levels in the body. No timing arrangement makes this combination safe — see the warnings above.
What should you watch out for when combining Mirtazapine and St Johns Wort?
Combining two or more serotonergic substances can raise the risk of serotonin syndrome, a potentially serious reaction. Ask a pharmacist, or the prescriber if any of these was prescribed, before you combine them. If any of these is a prescription, do not stop or change it on your own. Seek care for agitation, confusion, tremor, sweating, rapid heartbeat, or high fever. Avoid combining St. John's Wort with mirtazapine without consulting a healthcare provider due to potential interactions.
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Not medical advice
AI-written analysis generated August 11, 2026, checked by our interaction rules · How our analysis works