Supplement stacks / Rizatriptan + St Johns Wort
Can You Take Rizatriptan with St Johns Wort?
Rizatriptan is a medication used for treating migraines, while St. John's Wort is a herbal supplement often used for depression. There is a potential interaction between St. John's Wort and rizatriptan, as St. John's Wort may affect the metabolism of various medications, including those used for migraines. Caution is advised, and consultation with a healthcare provider is recommended before combining these substances.
Conservative, AI-assisted reading of publicly available medical sources (NIH, Mayo Clinic, WebMD, Examine.com). Informational only — it can't account for your medications, conditions, or genetics.
St. John's Wort may induce cytochrome P450 enzymes, potentially affecting the metabolism of rizatriptan.
Generally well-tolerated; however, it can cause side effects in some individuals.
Typical dosage: 5-10 mg as needed for migraine, not exceeding 30 mg in 24 hours
- Dizziness
- Fatigue
- Dry mouth
- Use with caution in patients with cardiovascular disease; consult healthcare provider.
Generally considered safe for short-term use; however, it can interact with many medications.
Typical dosage: 300-900 mg daily, divided into doses
- Gastrointestinal upset
- Fatigue
- Allergic skin reactions
- May cause photosensitivity; consult healthcare provider if taking other medications.
If combining, consider taking St. John's Wort in the morning and rizatriptan as needed for migraines, ensuring at least 4 hours apart.
- Consult with a healthcare provider before combining St. John's Wort with rizatriptan.
- Monitor for any unusual side effects or changes in migraine frequency.
- Combining two or more serotonergic substances can raise the risk of serotonin syndrome, a potentially serious reaction. Do not combine them without medical supervision, and seek care for agitation, confusion, tremor, sweating, rapid heartbeat, or high fever.
- Taking St. John's Wort may reduce the effectiveness of rizatriptan; consult a healthcare provider for alternatives.
Can you take Rizatriptan and St Johns Wort together?
Rizatriptan is a medication used for treating migraines, while St. John's Wort is a herbal supplement often used for depression. There is a potential interaction between St. John's Wort and rizatriptan, as St. John's Wort may affect the metabolism of various medications, including those used for migraines. Caution is advised, and consultation with a healthcare provider is recommended before combining these substances.
How safe is the Rizatriptan and St Johns Wort combination?
Our analysis of publicly available medical sources scores this combination 3/10 (high risk). This is an informational estimate, not medical advice — always confirm with a healthcare professional.
When should you take Rizatriptan and St Johns Wort?
If combining, consider taking St. John's Wort in the morning and rizatriptan as needed for migraines, ensuring at least 4 hours apart.
What should you watch out for when combining Rizatriptan and St Johns Wort?
Combining two or more serotonergic substances can raise the risk of serotonin syndrome, a potentially serious reaction. Do not combine them without medical supervision, and seek care for agitation, confusion, tremor, sweating, rapid heartbeat, or high fever. Taking St. John's Wort may reduce the effectiveness of rizatriptan; consult a healthcare provider for alternatives.
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Analysis generated August 11, 2026 · Sources include NIH, Mayo Clinic, WebMD, and Examine.com · How our analysis works