Supplement stacks / Rizatriptan + St Johns Wort
Can You Take Rizatriptan with St Johns Wort?
Rizatriptan and St Johns Wort: one interaction flagged, scored 3/10 (high risk). The count and score come from an AI-written analysis checked against our interaction rules, which can only make it stricter. Not medical advice.
Safety at a glance
This score comes from an AI-written analysis of the pair. Our interaction rules check it and can only make it stricter, never milder. Informational only: it can't account for your medications, conditions, or genetics.
What the AI-written analysis says
Rizatriptan is a medication used for treating migraines, while St. John's Wort is a herbal supplement often used for depression. There is a potential interaction between St. John's Wort and rizatriptan, as St. John's Wort may affect the metabolism of various medications, including those used for migraines. Caution is advised, and consultation with a healthcare provider is recommended before combining these substances.
Rizatriptan is a prescription medication. This page describes publicly documented interactions — it can't see your dose, your other prescriptions, or your labs. Discuss any supplement with the prescriber or pharmacist who manages this medication before combining.
Known interactions
St. John's Wort may induce cytochrome P450 enzymes, potentially affecting the metabolism of rizatriptan.
Rizatriptan
From the AI-written analysis.
Generally well-tolerated; however, it can cause side effects in some individuals.
Typical dosage: As prescribed or as directed on the label
- Dizziness
- Fatigue
- Dry mouth
- Use with caution in patients with cardiovascular disease; consult healthcare provider.
St. John's Wort
From the AI-written analysis.
Generally considered safe for short-term use; however, it can interact with many medications.
Typical dosage: 300-900 mg daily, divided into doses
- Gastrointestinal upset
- Fatigue
- Allergic skin reactions
- May cause photosensitivity; consult healthcare provider if taking other medications.
Timing
No timing arrangement makes this combination safe — see the warnings above.
Recommendations
- Consult with a healthcare provider before combining St. John's Wort with rizatriptan.
- Monitor for any unusual side effects or changes in migraine frequency.
Watch out for
- Combining two or more serotonergic substances can raise the risk of serotonin syndrome, a potentially serious reaction. Do not combine them without medical supervision, and seek care for agitation, confusion, tremor, sweating, rapid heartbeat, or high fever.
- Taking St. John's Wort may reduce the effectiveness of rizatriptan; consult a healthcare provider for alternatives.
Frequently asked questions
Can you take Rizatriptan and St Johns Wort together?
Rizatriptan and St Johns Wort: one interaction flagged, scored 3/10 (high risk). The count and score come from an AI-written analysis checked against our interaction rules, which can only make it stricter. Not medical advice.
What score does the Rizatriptan and St Johns Wort combination get?
The Rizatriptan and St Johns Wort combination is scored 3/10 (high risk). The score comes from an AI-written analysis checked against our interaction rules, which can only make it stricter. Not medical advice. Always confirm with a healthcare professional.
When should you take Rizatriptan and St Johns Wort?
No timing arrangement makes this combination safe — see the warnings above.
What should you watch out for when combining Rizatriptan and St Johns Wort?
Combining two or more serotonergic substances can raise the risk of serotonin syndrome, a potentially serious reaction. Do not combine them without medical supervision, and seek care for agitation, confusion, tremor, sweating, rapid heartbeat, or high fever. Taking St. John's Wort may reduce the effectiveness of rizatriptan; consult a healthcare provider for alternatives.
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Not medical advice
AI-written analysis generated August 11, 2026, checked by our interaction rules · How our analysis works