Supplement stacks / Rivaroxaban + St Johns Wort
Can You Take Rivaroxaban with St Johns Wort?
Rivaroxaban and St Johns Wort: one interaction flagged, scored 3/10 (high risk). The count and score come from an AI-written analysis checked against our interaction rules, which can only make it stricter. Not medical advice.
Safety at a glance
This score comes from an AI-written analysis of the pair. Our interaction rules check it and can only make it stricter, never milder. Informational only: it can't account for your medications, conditions, or genetics.
What the AI-written analysis says
St. John's Wort is known to induce cytochrome P450 enzymes, which can significantly reduce the effectiveness of rivaroxaban, an anticoagulant. This interaction poses a risk of increased thromboembolic events due to subtherapeutic levels of rivaroxaban. Therefore, combining these two substances is not recommended without medical supervision.
Rivaroxaban is a prescription medication. This page describes publicly documented interactions — it can't see your dose, your other prescriptions, or your labs. Discuss any supplement with the prescriber or pharmacist who manages this medication before combining.
Known interactions
St. John's Wort may decrease the plasma concentration of rivaroxaban, leading to reduced anticoagulant effect.
Rivaroxaban
From the AI-written analysis.
Effective anticoagulant; monitor for bleeding risks.
Typical dosage: As prescribed or as directed on the label
- Bleeding
- Anemia
- Nausea
- Monitor INR more frequently if taking with potential interacting substances.
St. John's Wort
From the AI-written analysis.
Generally considered safe for short-term use; however, it can interact with many medications.
Typical dosage: 300-900 mg daily, divided into doses
- Gastrointestinal upset
- Fatigue
- Allergic skin reactions
- May cause photosensitivity; consult healthcare provider if taking other medications, especially anticoagulants.
Timing
No timing arrangement makes this combination safe — see the warnings above.
Recommendations
- Avoid taking St. John's Wort while on rivaroxaban. Consult with a healthcare provider for alternative treatments for mood support.
Watch out for
- Do not combine St. John's Wort with rivaroxaban without consulting a healthcare provider. Monitor for signs of reduced anticoagulation.
Frequently asked questions
Can you take Rivaroxaban and St Johns Wort together?
Rivaroxaban and St Johns Wort: one interaction flagged, scored 3/10 (high risk). The count and score come from an AI-written analysis checked against our interaction rules, which can only make it stricter. Not medical advice.
What score does the Rivaroxaban and St Johns Wort combination get?
The Rivaroxaban and St Johns Wort combination is scored 3/10 (high risk). The score comes from an AI-written analysis checked against our interaction rules, which can only make it stricter. Not medical advice. Always confirm with a healthcare professional.
When should you take Rivaroxaban and St Johns Wort?
No timing arrangement makes this combination safe — see the warnings above.
What should you watch out for when combining Rivaroxaban and St Johns Wort?
Do not combine St. John's Wort with rivaroxaban without consulting a healthcare provider. Monitor for signs of reduced anticoagulation.
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Not medical advice
AI-written analysis generated August 11, 2026, checked by our interaction rules · How our analysis works