Supplement stacks / Atomoxetine + St Johns Wort

Can You Take Atomoxetine with St Johns Wort?

Combining atomoxetine with St. John's Wort poses potential risks due to the interaction between the two substances, which may affect the efficacy of atomoxetine and increase the risk of side effects. Caution is advised, and consultation with a healthcare provider is essential.

Safety at a glance
Medium risk
Safety score4/10

Conservative, AI-assisted reading of publicly available medical sources (NIH, Mayo Clinic, WebMD, Examine.com). Informational only — it can't account for your medications, conditions, or genetics.

Known interactions
Atomoxetine × St Johns Wort
high

St. John's Wort may reduce the effectiveness of atomoxetine by inducing liver enzymes that metabolize the drug, potentially leading to inadequate treatment of ADHD symptoms.

Atomoxetine

Generally well-tolerated but may cause side effects such as increased heart rate and blood pressure. Monitor for any cardiovascular changes.

Typical dosage: Follow manufacturer guidelines; typically starts at 40 mg/day.

Common side effects:
  • Nausea
  • Fatigue
  • Decreased appetite
  • Insomnia
  • Dry mouth
Warnings:
  • Monitor for cardiovascular side effects; consult healthcare provider if experiencing significant changes.
St Johns Wort

Generally considered safe but can interact with many medications, including antidepressants and other psychiatric medications.

Typical dosage: Follow manufacturer guidelines; typical dosage is around 300 mg taken three times daily.

Common side effects:
  • Photosensitivity
  • Gastrointestinal upset
  • Fatigue
  • Allergic skin reactions
Warnings:
  • Consult healthcare provider before use, especially if taking other medications.
Timing

If combining, consider taking them at different times of the day to minimize interaction risks, but consult your healthcare provider for personalized advice.

Watch out for
  • Consult your healthcare provider before combining these substances due to potential interactions.
Frequently asked questions

Can you take Atomoxetine and St Johns Wort together?

Combining atomoxetine with St. John's Wort poses potential risks due to the interaction between the two substances, which may affect the efficacy of atomoxetine and increase the risk of side effects. Caution is advised, and consultation with a healthcare provider is essential.

How safe is the Atomoxetine and St Johns Wort combination?

Our analysis of publicly available medical sources scores this combination 4/10 (medium risk). This is an informational estimate, not medical advice — always confirm with a healthcare professional.

When should you take Atomoxetine and St Johns Wort?

If combining, consider taking them at different times of the day to minimize interaction risks, but consult your healthcare provider for personalized advice.

What should you watch out for when combining Atomoxetine and St Johns Wort?

Consult your healthcare provider before combining these substances due to potential interactions.

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Analysis generated August 28, 2026 · Sources include NIH, Mayo Clinic, WebMD, and Examine.com · How our analysis works