Supplement stacks / Apixaban + St Johns Wort
Can You Take Apixaban with St Johns Wort?
St. John's Wort is known to induce cytochrome P450 enzymes, which can significantly reduce the effectiveness of apixaban, an anticoagulant. This interaction poses a risk of increased thromboembolic events due to reduced anticoagulation. Therefore, combining these substances is not recommended without medical supervision.
Conservative, AI-assisted reading of publicly available medical sources (NIH, Mayo Clinic, WebMD, Examine.com). Informational only — it can't account for your medications, conditions, or genetics.
St. John's Wort may decrease the effectiveness of apixaban by inducing CYP3A4 enzymes, leading to a higher risk of clotting.
Effective anticoagulant with a well-established safety profile when used as directed.
Typical dosage: 5 mg twice daily, may be reduced to 2.5 mg twice daily based on specific criteria.
- Bleeding
- Anemia
- Nausea
- Monitor for signs of bleeding; avoid combining with strong CYP3A4 inducers like St. John's Wort.
Generally safe for short-term use but can interact with many medications, including anticoagulants.
Typical dosage: 300-900 mg daily, divided into 2-3 doses
- Gastrointestinal upset
- Fatigue
- Allergic skin reactions
- May interact with anticoagulants like apixaban; consult healthcare provider before use.
- Avoid use in patients with bipolar disorder due to potential manic episodes.
If St. John's Wort is deemed necessary by a healthcare provider, it should be taken at least 4 hours apart from apixaban to minimize interaction risk.
- Avoid taking St. John's Wort while on apixaban. Consult your healthcare provider for alternative treatments for mood or anxiety.
- Do not combine St. John's Wort with apixaban due to the risk of reduced anticoagulant effect. Monitor INR more frequently if any changes in medication are made.
Can you take Apixaban and St Johns Wort together?
St. John's Wort is known to induce cytochrome P450 enzymes, which can significantly reduce the effectiveness of apixaban, an anticoagulant. This interaction poses a risk of increased thromboembolic events due to reduced anticoagulation. Therefore, combining these substances is not recommended without medical supervision.
How safe is the Apixaban and St Johns Wort combination?
Our analysis of publicly available medical sources scores this combination 3/10 (high risk). This is an informational estimate, not medical advice — always confirm with a healthcare professional.
When should you take Apixaban and St Johns Wort?
If St. John's Wort is deemed necessary by a healthcare provider, it should be taken at least 4 hours apart from apixaban to minimize interaction risk.
What should you watch out for when combining Apixaban and St Johns Wort?
Do not combine St. John's Wort with apixaban due to the risk of reduced anticoagulant effect. Monitor INR more frequently if any changes in medication are made.
Taking more than these two? Run your complete supplement list — plus any medications — through the live checker for a combined analysis.
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Analysis generated August 11, 2026 · Sources include NIH, Mayo Clinic, WebMD, and Examine.com · How our analysis works