Supplement stacks / Apixaban + St Johns Wort
Can You Take Apixaban with St Johns Wort?
Apixaban and St Johns Wort: one interaction flagged, scored 3/10 (high risk). The count and score come from an AI-written analysis checked against our interaction rules, which can only make it stricter. Not medical advice.
Safety at a glance
This score comes from an AI-written analysis of the pair. Our interaction rules check it and can only make it stricter, never milder. Informational only: it can't account for your medications, conditions, or genetics.
What the AI-written analysis says
St. John's Wort is known to induce cytochrome P450 enzymes, which can significantly reduce the effectiveness of apixaban, an anticoagulant. This interaction poses a risk of increased thromboembolic events due to reduced anticoagulation. Therefore, combining these substances is not recommended without medical supervision.
Apixaban is a prescription medication. This page describes publicly documented interactions — it can't see your dose, your other prescriptions, or your labs. Discuss any supplement with the prescriber or pharmacist who manages this medication before combining.
Known interactions
St. John's Wort may decrease the effectiveness of apixaban by inducing CYP3A4 enzymes, leading to a higher risk of clotting.
Apixaban
From the AI-written analysis.
Effective anticoagulant with a well-established safety profile when used as directed.
Typical dosage: As prescribed or as directed on the label
- Bleeding
- Anemia
- Nausea
- Monitor for signs of bleeding; avoid combining with strong CYP3A4 inducers like St. John's Wort.
St. John's Wort
From the AI-written analysis.
Generally safe for short-term use but can interact with many medications, including anticoagulants.
Typical dosage: 300-900 mg daily, divided into 2-3 doses
- Gastrointestinal upset
- Fatigue
- Allergic skin reactions
- May interact with anticoagulants like apixaban; consult healthcare provider before use.
- Avoid use in patients with bipolar disorder due to potential manic episodes.
Timing
No timing arrangement makes this combination safe — see the warnings above.
Recommendations
- Avoid taking St. John's Wort while on apixaban. Consult your healthcare provider for alternative treatments for mood or anxiety.
Watch out for
- Do not combine St. John's Wort with apixaban due to the risk of reduced anticoagulant effect. Monitor INR more frequently if any changes in medication are made.
Frequently asked questions
Can you take Apixaban and St Johns Wort together?
Apixaban and St Johns Wort: one interaction flagged, scored 3/10 (high risk). The count and score come from an AI-written analysis checked against our interaction rules, which can only make it stricter. Not medical advice.
What score does the Apixaban and St Johns Wort combination get?
The Apixaban and St Johns Wort combination is scored 3/10 (high risk). The score comes from an AI-written analysis checked against our interaction rules, which can only make it stricter. Not medical advice. Always confirm with a healthcare professional.
When should you take Apixaban and St Johns Wort?
No timing arrangement makes this combination safe — see the warnings above.
What should you watch out for when combining Apixaban and St Johns Wort?
Do not combine St. John's Wort with apixaban due to the risk of reduced anticoagulant effect. Monitor INR more frequently if any changes in medication are made.
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Not medical advice
AI-written analysis generated August 11, 2026, checked by our interaction rules · How our analysis works