Supplement stacks / Melatonin + St Johns Wort
Can You Take Melatonin with St Johns Wort?
Melatonin and St Johns Wort: one interaction flagged, scored 6/10 (medium risk). The count and score come from an AI-written analysis checked against our interaction rules, which can only make it stricter. Not medical advice.
Safety at a glance
This score comes from an AI-written analysis of the pair. Our interaction rules check it and can only make it stricter, never milder. Informational only: it can't account for your medications, conditions, or genetics.
What the AI-written analysis says
Melatonin and St. John's Wort can be taken together, but caution is advised due to potential interactions. Melatonin is primarily used for sleep regulation, while St. John's Wort is often used for mood enhancement. Both supplements have limited evidence quality, and their interactions are not fully understood. Consulting a healthcare provider is recommended before combining these supplements.
Known interactions
St. John's Wort may affect the metabolism of melatonin, potentially altering its effectiveness.
Melatonin
From the AI-written analysis.
Generally considered safe for short-term use; long-term safety is less established.
Typical dosage: 1-5 mg taken 30-60 minutes before bedtime
- Drowsiness
- Dizziness
- Headache
- May cause daytime drowsiness; avoid driving after use.
- Consult healthcare provider if pregnant or nursing.
St. John's Wort
From the AI-written analysis.
Generally safe for most people; may cause photosensitivity in some individuals.
Typical dosage: 300-900 mg daily, divided into doses
- Gastrointestinal upset
- Fatigue
- Dry mouth
- Can interact with various medications, including antidepressants and birth control.
- Consult healthcare provider if pregnant or nursing.
Timing
Melatonin should be taken in the evening for sleep support, while St. John's Wort can be taken in the morning or early afternoon to support mood.
Recommendations
- Consult a healthcare provider before starting this combination.
- Monitor for any unusual side effects when taking both supplements.
Watch out for
- Take melatonin at least 4 hours apart from St. John's Wort to minimize potential interaction.
Frequently asked questions
Can you take Melatonin and St Johns Wort together?
Melatonin and St Johns Wort: one interaction flagged, scored 6/10 (medium risk). The count and score come from an AI-written analysis checked against our interaction rules, which can only make it stricter. Not medical advice.
What score does the Melatonin and St Johns Wort combination get?
The Melatonin and St Johns Wort combination is scored 6/10 (medium risk). The score comes from an AI-written analysis checked against our interaction rules, which can only make it stricter. Not medical advice. Always confirm with a healthcare professional.
When should you take Melatonin and St Johns Wort?
Melatonin should be taken in the evening for sleep support, while St. John's Wort can be taken in the morning or early afternoon to support mood.
What should you watch out for when combining Melatonin and St Johns Wort?
Take melatonin at least 4 hours apart from St. John's Wort to minimize potential interaction.
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Not medical advice
AI-written analysis generated August 11, 2026, checked by our interaction rules · How our analysis works