Supplement stacks / Amiodarone + St Johns Wort
Can You Take Amiodarone with St Johns Wort?
Amiodarone and St Johns Wort: one interaction flagged, scored 3/10 (high risk). The count and score come from an AI-written analysis checked against our interaction rules, which can only make it stricter. Not medical advice.
Safety at a glance
This score comes from an AI-written analysis of the pair. Our interaction rules check it and can only make it stricter, never milder. Informational only: it can't account for your medications, conditions, or genetics.
What the AI-written analysis says
St. John's Wort is known to interact with many medications, including amiodarone, potentially reducing its effectiveness. This combination poses significant risks and should be avoided unless supervised by a healthcare provider.
Amiodarone is a prescription medication. This page describes publicly documented interactions — it can't see your dose, your other prescriptions, or your labs. Discuss any supplement with the prescriber or pharmacist who manages this medication before combining.
Known interactions
St. John's Wort may induce cytochrome P450 enzymes, potentially decreasing the plasma concentration of amiodarone, leading to reduced therapeutic effects.
Amiodarone
From the AI-written analysis.
Effective antiarrhythmic medication but has a complex side effect profile.
Typical dosage: As prescribed or as directed on the label
- Thyroid dysfunction
- Pulmonary toxicity
- Liver enzyme elevation
- Regular monitoring of thyroid function and liver enzymes is recommended.
- Avoid use with drugs that prolong QT interval.
St. John's Wort
From the AI-written analysis.
Generally considered safe for short-term use but can interact with various medications.
Typical dosage: 300-900 mg daily, divided into doses
- Gastrointestinal upset
- Fatigue
- Allergic skin reactions
- May cause photosensitivity; avoid excessive sun exposure.
- Consult healthcare provider before use with other medications.
Timing
Take as prescribed — we do not schedule prescription medications. Follow the label or your prescriber, and ask your pharmacist before changing when you take it. If considering other supplements, consult your healthcare provider for appropriate timing.
Recommendations
- Avoid taking St. John's Wort while on amiodarone.
- Consult with a healthcare provider for alternative treatments for mood support.
Watch out for
- Do not combine St. John's Wort with amiodarone due to the risk of reduced drug efficacy. Consult your healthcare provider for alternatives.
Frequently asked questions
Can you take Amiodarone and St Johns Wort together?
Amiodarone and St Johns Wort: one interaction flagged, scored 3/10 (high risk). The count and score come from an AI-written analysis checked against our interaction rules, which can only make it stricter. Not medical advice.
What score does the Amiodarone and St Johns Wort combination get?
The Amiodarone and St Johns Wort combination is scored 3/10 (high risk). The score comes from an AI-written analysis checked against our interaction rules, which can only make it stricter. Not medical advice. Always confirm with a healthcare professional.
When should you take Amiodarone and St Johns Wort?
Take as prescribed — we do not schedule prescription medications. Follow the label or your prescriber, and ask your pharmacist before changing when you take it. If considering other supplements, consult your healthcare provider for appropriate timing.
What should you watch out for when combining Amiodarone and St Johns Wort?
Do not combine St. John's Wort with amiodarone due to the risk of reduced drug efficacy. Consult your healthcare provider for alternatives.
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Not medical advice
AI-written analysis generated August 11, 2026, checked by our interaction rules · How our analysis works