Supplement stacks / Cyclosporine + St Johns Wort
Can You Take Cyclosporine with St Johns Wort?
St. John's Wort is known to induce cytochrome P450 enzymes, which can significantly reduce the effectiveness of cyclosporine, a medication that requires careful blood level monitoring. This interaction poses a risk of transplant rejection or treatment failure. Therefore, combining these substances is not recommended without medical supervision.
Conservative, AI-assisted reading of publicly available medical sources (NIH, Mayo Clinic, WebMD, Examine.com). Informational only — it can't account for your medications, conditions, or genetics.
St. John's Wort may decrease the plasma concentration of cyclosporine, potentially leading to reduced efficacy.
Immunosuppressant medication with a narrow therapeutic index; requires monitoring of blood levels.
Typical dosage: 3-5 mg/kg/day, adjusted based on blood levels
- Kidney dysfunction
- Hypertension
- Increased risk of infections
- Monitor blood levels regularly; avoid use with St. John's Wort.
Generally safe for most individuals but can interact with various medications, especially those metabolized by the liver.
Typical dosage: 300-900 mg daily, divided into doses
- Gastrointestinal upset
- Fatigue
- Allergic skin reactions
- Avoid use with cyclosporine; consult healthcare provider before use with other medications.
If supplements are considered, they should be taken at least 4 hours apart from cyclosporine to minimize interaction risks.
- Consult with a healthcare provider before considering any supplements while on cyclosporine.
- Do not take St. John's Wort while on cyclosporine; it may lead to decreased effectiveness of the medication.
Can you take Cyclosporine and St Johns Wort together?
St. John's Wort is known to induce cytochrome P450 enzymes, which can significantly reduce the effectiveness of cyclosporine, a medication that requires careful blood level monitoring. This interaction poses a risk of transplant rejection or treatment failure. Therefore, combining these substances is not recommended without medical supervision.
How safe is the Cyclosporine and St Johns Wort combination?
Our analysis of publicly available medical sources scores this combination 3/10 (high risk). This is an informational estimate, not medical advice — always confirm with a healthcare professional.
When should you take Cyclosporine and St Johns Wort?
If supplements are considered, they should be taken at least 4 hours apart from cyclosporine to minimize interaction risks.
What should you watch out for when combining Cyclosporine and St Johns Wort?
Do not take St. John's Wort while on cyclosporine; it may lead to decreased effectiveness of the medication.
Taking more than these two? Run your complete supplement list — plus any medications — through the live checker for a combined analysis.
Analyze my stackGenetics change how you process supplements like these. Upload raw 23andMe or Ancestry data for a personalized supplement report.
See the DNA reportNot medical advice
Analysis generated August 11, 2026 · Sources include NIH, Mayo Clinic, WebMD, and Examine.com · How our analysis works