Supplement stacks / Cyclosporine + St Johns Wort
Can You Take Cyclosporine with St Johns Wort?
Cyclosporine and St Johns Wort: one interaction flagged, scored 3/10 (high risk). The count and score come from an AI-written analysis checked against our interaction rules, which can only make it stricter. Not medical advice.
Safety at a glance
This score comes from an AI-written analysis of the pair. Our interaction rules check it and can only make it stricter, never milder. Informational only: it can't account for your medications, conditions, or genetics.
What the AI-written analysis says
St. John's Wort is known to induce cytochrome P450 enzymes, which can significantly reduce the effectiveness of cyclosporine, a medication that requires careful blood level monitoring. This interaction poses a risk of transplant rejection or treatment failure. Therefore, combining these substances is not recommended without medical supervision.
Cyclosporine is a prescription medication. This page describes publicly documented interactions — it can't see your dose, your other prescriptions, or your labs. Discuss any supplement with the prescriber or pharmacist who manages this medication before combining.
Known interactions
St. John's Wort may decrease the plasma concentration of cyclosporine, potentially leading to reduced efficacy.
Cyclosporine
From the AI-written analysis.
Immunosuppressant medication with a narrow therapeutic index; requires monitoring of blood levels.
Typical dosage: As prescribed or as directed on the label
- Kidney dysfunction
- Hypertension
- Increased risk of infections
- Monitor blood levels regularly; avoid use with St. John's Wort.
St. John's Wort
From the AI-written analysis.
Generally safe for most individuals but can interact with various medications, especially those metabolized by the liver.
Typical dosage: 300-900 mg daily, divided into doses
- Gastrointestinal upset
- Fatigue
- Allergic skin reactions
- Avoid use with cyclosporine; consult healthcare provider before use with other medications.
Timing
No timing arrangement makes this combination safe — see the warnings above.
Recommendations
- Consult with a healthcare provider before considering any supplements while on cyclosporine.
Watch out for
- St. Johns Wort strongly induces the liver enzyme (CYP3A4) and gut transporter (P-glycoprotein) that clear tacrolimus, cyclosporine, sirolimus, and everolimus. Published cases document blood levels falling below the therapeutic range with acute organ-transplant rejection as the result. This combination is widely listed as one to avoid entirely — contact the transplant team or prescriber before any St. Johns Wort use, and tell them right away if the two have already been combined so levels can be checked.
- Do not take St. John's Wort while on cyclosporine; it may lead to decreased effectiveness of the medication.
Frequently asked questions
Can you take Cyclosporine and St Johns Wort together?
Cyclosporine and St Johns Wort: one interaction flagged, scored 3/10 (high risk). The count and score come from an AI-written analysis checked against our interaction rules, which can only make it stricter. Not medical advice.
What score does the Cyclosporine and St Johns Wort combination get?
The Cyclosporine and St Johns Wort combination is scored 3/10 (high risk). The score comes from an AI-written analysis checked against our interaction rules, which can only make it stricter. Not medical advice. Always confirm with a healthcare professional.
When should you take Cyclosporine and St Johns Wort?
No timing arrangement makes this combination safe — see the warnings above.
What should you watch out for when combining Cyclosporine and St Johns Wort?
St. Johns Wort strongly induces the liver enzyme (CYP3A4) and gut transporter (P-glycoprotein) that clear tacrolimus, cyclosporine, sirolimus, and everolimus. Published cases document blood levels falling below the therapeutic range with acute organ-transplant rejection as the result. This combination is widely listed as one to avoid entirely — contact the transplant team or prescriber before any St. Johns Wort use, and tell them right away if the two have already been combined so levels can be checked. Do not take St. John's Wort while on cyclosporine; it may lead to decreased effectiveness of the medication.
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Not medical advice
AI-written analysis generated August 11, 2026, checked by our interaction rules · How our analysis works