Supplement stacks / Digoxin + St Johns Wort
Can You Take Digoxin with St Johns Wort?
Digoxin and St Johns Wort: one interaction flagged, scored 3/10 (high risk). The count and score come from an AI-written analysis checked against our interaction rules, which can only make it stricter. Not medical advice.
Safety at a glance
This score comes from an AI-written analysis of the pair. Our interaction rules check it and can only make it stricter, never milder. Informational only: it can't account for your medications, conditions, or genetics.
What the AI-written analysis says
St. John's Wort may interact with digoxin, potentially affecting its efficacy and safety. Caution is advised when considering the use of St. John's Wort alongside digoxin, and consultation with a healthcare provider is essential.
Digoxin is a prescription medication. This page describes publicly documented interactions — it can't see your dose, your other prescriptions, or your labs. Discuss any supplement with the prescriber or pharmacist who manages this medication before combining.
Known interactions
St. John's Wort may induce cytochrome P450 enzymes, which could lead to decreased levels of digoxin in the body, potentially reducing its effectiveness.
Digoxin
From the AI-written analysis.
Effective for heart conditions but requires careful monitoring due to narrow therapeutic index.
Typical dosage: As prescribed or as directed on the label
- Nausea
- Vomiting
- Dizziness
- Visual disturbances
- Monitor for signs of digoxin toxicity, especially if taking other interacting substances.
- Regular blood level checks may be necessary.
St. John's Wort
From the AI-written analysis.
Generally considered safe for short-term use; however, it can interact with various medications.
Typical dosage: 300-900 mg daily, divided into doses
- Gastrointestinal upset
- Fatigue
- Allergic skin reactions
- Consult healthcare provider before use, especially if taking other medications like digoxin.
- May cause photosensitivity.
Also commonly mentioned
These come up in questions about this combination. They are not part of the pair above. From the AI-written analysis.
Magnesium
Generally safe; important for heart health and may help mitigate some side effects of digoxin.
Typical dosage: 310-420 mg daily, depending on age and gender
- Diarrhea
- Nausea
- Abdominal cramping
- High doses can lead to hypermagnesemia; consult healthcare provider if on digoxin.
Coenzyme Q10
Generally safe; may support heart health and improve energy levels.
Typical dosage: 100-200 mg daily
- Mild gastrointestinal upset
- Insomnia
- Consult healthcare provider if on digoxin; may affect blood pressure.
Omega-3 Fatty Acids
Generally safe; beneficial for cardiovascular health.
Typical dosage: 1000-3000 mg daily
- Fishy aftertaste
- Gastrointestinal discomfort
- Consult healthcare provider if on anticoagulants or digoxin.
Timing
St. John's Wort should be taken consistently at the same time each day to maintain stable levels in the body.
Recommendations
- Consult with a healthcare provider before starting St. John's Wort while on digoxin.
- Consider monitoring digoxin levels more frequently if St. John's Wort is initiated.
Watch out for
- Digoxin has a narrow safety margin. Real licorice (glycyrrhizin) can deplete potassium, and low potassium makes digoxin substantially more toxic at the same blood level. Hawthorn can add to digoxin's effects on the heart, while St. Johns Wort induces the transporter that clears digoxin — lowering blood levels by about 25% in studies, so the medication may not work as intended. None of these belong alongside digoxin without the prescriber's involvement and blood-level and electrolyte monitoring. Seek care promptly for nausea, vision changes, confusion, or an irregular heartbeat.
- No timing arrangement makes this combination safe — see the warnings above.
Frequently asked questions
Can you take Digoxin and St Johns Wort together?
Digoxin and St Johns Wort: one interaction flagged, scored 3/10 (high risk). The count and score come from an AI-written analysis checked against our interaction rules, which can only make it stricter. Not medical advice.
What score does the Digoxin and St Johns Wort combination get?
The Digoxin and St Johns Wort combination is scored 3/10 (high risk). The score comes from an AI-written analysis checked against our interaction rules, which can only make it stricter. Not medical advice. Always confirm with a healthcare professional.
When should you take Digoxin and St Johns Wort?
St. John's Wort should be taken consistently at the same time each day to maintain stable levels in the body.
What should you watch out for when combining Digoxin and St Johns Wort?
Digoxin has a narrow safety margin. Real licorice (glycyrrhizin) can deplete potassium, and low potassium makes digoxin substantially more toxic at the same blood level. Hawthorn can add to digoxin's effects on the heart, while St. Johns Wort induces the transporter that clears digoxin — lowering blood levels by about 25% in studies, so the medication may not work as intended. None of these belong alongside digoxin without the prescriber's involvement and blood-level and electrolyte monitoring. Seek care promptly for nausea, vision changes, confusion, or an irregular heartbeat. No timing arrangement makes this combination safe — see the warnings above.
Check your full stack
Taking more than these two? Add everything you take, medicines included, to your list. We check each supplement on your list against the rest of it, and name anything we could not check. Free, and you don’t need an account.
Analyze my stackWhat your DNA adds
Some genes in a raw 23andMe or AncestryDNA file are linked to how the body handles nutrients. The DNA report says what yours are linked to and, where there is one, which blood test would tell you more.
See the DNA reportRelated combinations
Not medical advice
AI-written analysis generated August 11, 2026, checked by our interaction rules · How our analysis works