Supplement stacks / Digoxin + Licorice Root
Can You Take Digoxin with Licorice Root?
Taking digoxin with licorice root may pose risks due to potential interactions that can affect digoxin levels and heart function. Caution is advised.
Conservative, AI-assisted reading of publicly available medical sources (NIH, Mayo Clinic, WebMD, Examine.com). Informational only — it can't account for your medications, conditions, or genetics.
Digoxin is a prescription medication. This page describes publicly documented interactions — it can't see your dose, your other prescriptions, or your labs. Discuss any supplement with the prescriber or pharmacist who manages this medication before combining.
Licorice root can increase the risk of digoxin toxicity by causing potassium depletion, which may lead to arrhythmias. Monitor potassium levels and consult your healthcare provider.
Digoxin has a narrow therapeutic index; toxicity can occur easily, especially with electrolyte imbalances.
Typical dosage: Follow manufacturer guidelines; varies by condition.
- Nausea
- Fatigue
- Visual disturbances
- Monitor for signs of toxicity, especially if potassium levels are low.
- Consult healthcare provider before combining with other substances.
Can cause hypertension and hypokalemia, especially in high doses or prolonged use.
Typical dosage: Follow manufacturer guidelines; varies by product.
- Headache
- Hypertension
- Edema
- Use with caution in individuals with heart conditions or hypertension.
- Consult healthcare provider before use, especially with digoxin.
Consider taking licorice root at least 4 hours apart from digoxin to minimize interaction risks.
- Digoxin has a narrow safety margin. Real licorice (glycyrrhizin) can deplete potassium, and low potassium makes digoxin substantially more toxic at the same blood level. Hawthorn can add to digoxin's effects on the heart, while St. Johns Wort induces the transporter that clears digoxin — lowering blood levels by about 25% in studies, so the medication may not work as intended. None of these belong alongside digoxin without the prescriber's involvement and blood-level and electrolyte monitoring. Seek care promptly for nausea, vision changes, confusion, or an irregular heartbeat.
- Consult your healthcare provider before combining these substances due to potential risks.
Can you take Digoxin and Licorice Root together?
Taking digoxin with licorice root may pose risks due to potential interactions that can affect digoxin levels and heart function. Caution is advised.
How safe is the Digoxin and Licorice Root combination?
Our analysis of publicly available medical sources scores this combination 3/10 (high risk). This is an informational estimate, not medical advice — always confirm with a healthcare professional.
When should you take Digoxin and Licorice Root?
Consider taking licorice root at least 4 hours apart from digoxin to minimize interaction risks.
What should you watch out for when combining Digoxin and Licorice Root?
Digoxin has a narrow safety margin. Real licorice (glycyrrhizin) can deplete potassium, and low potassium makes digoxin substantially more toxic at the same blood level. Hawthorn can add to digoxin's effects on the heart, while St. Johns Wort induces the transporter that clears digoxin — lowering blood levels by about 25% in studies, so the medication may not work as intended. None of these belong alongside digoxin without the prescriber's involvement and blood-level and electrolyte monitoring. Seek care promptly for nausea, vision changes, confusion, or an irregular heartbeat. Consult your healthcare provider before combining these substances due to potential risks.
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Analysis generated September 2, 2026 · Sources include NIH, Mayo Clinic, WebMD, and Examine.com · How our analysis works