Supplement stacks / Digoxin + Licorice Root
Can You Take Digoxin with Licorice Root?
Digoxin and Licorice Root: one interaction flagged, scored 3/10 (high risk). The count and score come from an AI-written analysis checked against our interaction rules, which can only make it stricter. Not medical advice.
Safety at a glance
High riskThis score comes from an AI-written analysis of the pair. Our interaction rules check it and can only make it stricter, never milder. Informational only: it can't account for your medications, conditions, or genetics.
What the AI-written analysis says
Taking digoxin with licorice root may pose risks due to potential interactions that can affect digoxin levels and heart function. Caution is advised.
Digoxin is a prescription medication. This page describes publicly documented interactions — it can't see your dose, your other prescriptions, or your labs. Discuss any supplement with the prescriber or pharmacist who manages this medication before combining.
Known interactions
Licorice root can increase the risk of digoxin toxicity by causing potassium depletion, which may lead to arrhythmias. Monitor potassium levels and consult your healthcare provider.
Digoxin
From the AI-written analysis.
Digoxin has a narrow therapeutic index; toxicity can occur easily, especially with electrolyte imbalances.
Typical dosage: As prescribed or as directed on the label
- Nausea
- Fatigue
- Visual disturbances
- Monitor for signs of toxicity, especially if potassium levels are low.
- Consult healthcare provider before combining with other substances.
Licorice Root
From the AI-written analysis.
Can cause hypertension and hypokalemia, especially in high doses or prolonged use.
Typical dosage: Follow manufacturer guidelines; varies by product.
- Headache
- Hypertension
- Edema
- Use with caution in individuals with heart conditions or hypertension.
- Consult healthcare provider before use, especially with digoxin.
Timing
No timing arrangement makes this combination safe — see the warnings above.
Watch out for
- Digoxin has a narrow safety margin. Real licorice (glycyrrhizin) can deplete potassium, and low potassium makes digoxin substantially more toxic at the same blood level. Hawthorn can add to digoxin's effects on the heart, while St. Johns Wort induces the transporter that clears digoxin — lowering blood levels by about 25% in studies, so the medication may not work as intended. None of these belong alongside digoxin without the prescriber's involvement and blood-level and electrolyte monitoring. Seek care promptly for nausea, vision changes, confusion, or an irregular heartbeat.
- Consult your healthcare provider before combining these substances due to potential risks.
Frequently asked questions
Can you take Digoxin and Licorice Root together?
Digoxin and Licorice Root: one interaction flagged, scored 3/10 (high risk). The count and score come from an AI-written analysis checked against our interaction rules, which can only make it stricter. Not medical advice.
What score does the Digoxin and Licorice Root combination get?
The Digoxin and Licorice Root combination is scored 3/10 (high risk). The score comes from an AI-written analysis checked against our interaction rules, which can only make it stricter. Not medical advice. Always confirm with a healthcare professional.
When should you take Digoxin and Licorice Root?
No timing arrangement makes this combination safe — see the warnings above.
What should you watch out for when combining Digoxin and Licorice Root?
Digoxin has a narrow safety margin. Real licorice (glycyrrhizin) can deplete potassium, and low potassium makes digoxin substantially more toxic at the same blood level. Hawthorn can add to digoxin's effects on the heart, while St. Johns Wort induces the transporter that clears digoxin — lowering blood levels by about 25% in studies, so the medication may not work as intended. None of these belong alongside digoxin without the prescriber's involvement and blood-level and electrolyte monitoring. Seek care promptly for nausea, vision changes, confusion, or an irregular heartbeat. Consult your healthcare provider before combining these substances due to potential risks.
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Not medical advice
This analysis is based on general supplement information. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult qualified healthcare providers before starting any supplement regimen.
AI-written analysis generated September 2, 2026, checked by our interaction rules · How our analysis works