Sample report: fictional genotype, real format.

The sections below are the ones your report has, written the same way. Yours is read from your own 23andMe or AncestryDNA raw file.

Sample DNA report

The full report for "Sample S.", a fictional profile covering all 9 genetic variants we analyze.

DNA report

CanIStackThis.com · Read from your file on 1 Aug 2026 · 9 of 9 panel variants found in your file

How to read this report. Your DNA file shows which version of a few genes you carry. For each one, this report tells you what that version is linked to, where to read more and, where there is one, which blood test would tell you more and a question to bring to your doctor. A gene result cannot show how much of anything you need, so the report gives no amounts. It is information, not a diagnosis: confirm anything that matters with a test your doctor orders, and talk to your doctor before a big change.

What your results are linked to

Folate (MTHFR): somewhat lower activity. One copy of the C677T variant. The C677T variant makes this enzyme less active. The clearest link to higher homocysteine is in people with two copies, especially when folate status is low.

Vitamin B12 (FUT2): one A copy. One copy of the A version (GA). In one large study, average B12 was higher in people with AA at this marker than in people with GA or GG; a group's average does not tell one person's level.

Caffeine (CYP1A2): two C copies. Two copies of the C version (CC). In one study, people with CC broke caffeine down more slowly than people with AA, but only among smokers; among non-smokers the three results did not differ.

Vitamin D (VDR): two T copies. Two copies of the T version (TT). BsmI is one of the most studied markers in this gene, but what it does to the receptor is largely unknown, and it is probably not functional itself.

Fat transport (APOE): no e4. No copies of e4. This report links nothing further to this result.

Vitamin A from beta-carotene (BCMO1): somewhat lower conversion. One copy of the 379V variant. In one study, people carrying the 379V variant turned beta-carotene into vitamin A less well.

Dopamine clearance (COMT): two Met copies. Two copies of the Met version (AA). The Met version is linked to lower activity of this enzyme than the Val version, in studies of brain tissue.

Findings

Where your result differs from the common version (6)

MTHFR C677T (rs1801133), genotype CT, differs from the common version

Result: One copy of the C677T variant.

Linked to: MTHFR makes the enzyme that turns folate into the form found in blood, which the body needs to turn homocysteine into methionine. The C677T variant makes this enzyme less active. The clearest link to higher homocysteine is in people with two copies, especially when folate status is low. This report reads your DNA file; it does not measure your folate or homocysteine.

What would tell you: Two blood tests show how this pathway is working: folate and homocysteine. Homocysteine also rises for other reasons, such as low B12 or kidney problems. Folate (https://medlineplus.gov/ency/article/003686.htm) Homocysteine (https://medlineplus.gov/lab-tests/homocysteine-test/)

Question for your doctor: My DNA report shows one copy of the MTHFR C677T variant. Is a folate or homocysteine blood test worth doing for me?

Nutrients this finding is about: Methylfolate (5-MTHF), Vitamin B12, B complex

Note: If you could become pregnant: NIH notes that the CDC's folic acid advice applies even with this variant, so ask your doctor before changing the form of folate you take.

About these names: NIH says research on folate supplements for people with C677T is inconclusive, and that some of them might benefit from the methylated form (5-MTHF). The CDC says people with an MTHFR variant can process all types of folate, including folic acid. The body uses folate, B12 and B6 to break down homocysteine.

Read more: MTHFR gene, MedlinePlus Genetics (NIH), https://medlineplus.gov/genetics/gene/mthfr/

Read more: Folate fact sheet, NIH Office of Dietary Supplements, https://ods.od.nih.gov/factsheets/Folate-HealthProfessional/

Read more: MTHFR and folic acid, CDC, https://www.cdc.gov/folic-acid/data-research/mthfr/index.html

CYP1A2 (rs762551), genotype CC, differs from the common version

Result: Two copies of the C version (CC).

Linked to: CYP1A2 is the enzyme that breaks down most of the caffeine you take in. In one study, people with CC broke caffeine down more slowly than people with AA, but only among smokers; among non-smokers the three results did not differ. Age, hormones, smoking, diet and liver health also change how caffeine is cleared, and some medicines and health conditions change how sensitive people are to it.

What would tell you: No blood test in this report measures how you clear caffeine. The FDA notes wide variation in how sensitive people are to caffeine and how fast they clear it.

Question for your doctor: Do any of my medicines or health conditions change how caffeine affects me?

Nutrients this finding is about: Caffeine

About these names: Caffeine interacts with many medications; the check shows how it sits beside what you take.

Read more: Nehlig, 2018 (research review), PubMed (NIH), https://pubmed.ncbi.nlm.nih.gov/29514871/

Read more: Sachse et al., 1999 (research paper), PubMed (NIH), https://pubmed.ncbi.nlm.nih.gov/10233211/

Read more: How much caffeine is too much?, U.S. Food and Drug Administration, https://www.fda.gov/consumers/consumer-updates/spilling-beans-how-much-caffeine-too-much

COMT Val158Met (rs4680), genotype AA, differs from the common version

Result: Two copies of the Met version (AA).

Linked to: COMT makes an enzyme that helps break down dopamine and other chemical messengers in the front of the brain. The Met version is linked to lower activity of this enzyme than the Val version, in studies of brain tissue. The link between one DNA variant and complex traits such as focus or stress is usually complicated, and this report does not try to read those from it.

What would tell you: This report has no blood test to point to for this marker.

Question for your doctor: COMT also breaks down some medicines, such as levodopa (L-DOPA). Does my COMT result matter for anything I take?

Read more: COMT gene, MedlinePlus Genetics (NIH), https://medlineplus.gov/genetics/gene/comt/

Read more: Chen et al., 2004 (research paper), PubMed (NIH), https://pubmed.ncbi.nlm.nih.gov/15457404/

Read more: Lachman et al., 1996 (research paper), PubMed (NIH), https://pubmed.ncbi.nlm.nih.gov/8807664/

FUT2 (rs602662), genotype GA, differs from the common version

Result: One copy of the A version (GA).

Linked to: Large studies link this FUT2 marker to vitamin B12 levels in the blood. In one large study, average B12 was higher in people with AA at this marker than in people with GA or GG; a group's average does not tell one person's level. This report reads your DNA file; it does not measure your B12.

What would tell you: A vitamin B12 blood test measures your B12. Methylmalonic acid (MMA) is the most sensitive marker of B12 status, and homocysteine also rises as B12 falls. Vitamin B12 (https://medlineplus.gov/ency/article/003705.htm) Methylmalonic acid (MMA) (https://medlineplus.gov/lab-tests/methylmalonic-acid-mma-test/) Homocysteine (https://medlineplus.gov/lab-tests/homocysteine-test/)

Question for your doctor: My DNA report links a FUT2 marker to B12 levels. Is a B12 blood test worth doing for me, would an MMA test add anything, and do any of my medicines, such as metformin or acid reducers (proton pump inhibitors), affect B12?

Nutrients this finding is about: Vitamin B12

About these names: NIH says evidence suggests no difference between B12 swallowed and B12 dissolved under the tongue (sublingual).

Read more: Tanaka et al., 2009 (research paper), PubMed (NIH), https://pubmed.ncbi.nlm.nih.gov/19303062/

Read more: Hazra et al., 2008 (research paper), PubMed (NIH), https://pubmed.ncbi.nlm.nih.gov/18776911/

Read more: Vitamin B12 fact sheet, NIH Office of Dietary Supplements, https://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/

BCMO1 A379V (rs7501331), genotype CT, differs from the common version

Result: One copy of the 379V variant.

Linked to: BCMO1 makes the enzyme that turns beta-carotene from plants into vitamin A. In one study, people carrying the 379V variant turned beta-carotene into vitamin A less well. Preformed vitamin A, found in dairy, eggs and fish, is already vitamin A and does not need this step.

What would tell you: A vitamin A blood test measures vitamin A in the blood, but NIH notes it is not always a reliable guide, because blood levels do not fall until the body's stores are almost used up. Vitamin A (https://medlineplus.gov/ency/article/003570.htm)

Question for your doctor: My DNA report shows a BCMO1 variant linked to turning less beta-carotene into vitamin A. Is my vitamin A intake worth looking at, and does it matter if I am or could become pregnant?

Nutrients this finding is about: Vitamin A (retinyl palmitate)

Note: If you are or might be pregnant or breastfeeding, NIH advises against large amounts of preformed vitamin A from supplements; ask your doctor first.

About these names: NIH notes that too much preformed vitamin A during pregnancy can cause birth defects, and that beta-carotene is not known to.

Read more: Vitamin A fact sheet, NIH Office of Dietary Supplements, https://ods.od.nih.gov/factsheets/VitaminA-HealthProfessional/

Read more: Leung et al., 2009 (research paper), PubMed (NIH), https://pubmed.ncbi.nlm.nih.gov/19103647/

Read more: Vitamin A, for consumers, NIH Office of Dietary Supplements, https://ods.od.nih.gov/factsheets/VitaminA-Consumer/

VDR BsmI (rs1544410), genotype TT, differs from the common version

Result: Two copies of the T version (TT).

Linked to: VDR makes the receptor that active vitamin D attaches to; together they help control how much calcium and phosphate the body absorbs from food. BsmI is one of the most studied markers in this gene, but what it does to the receptor is largely unknown, and it is probably not functional itself. So this report cannot say whether this result changes how much vitamin D you need.

What would tell you: The 25-hydroxy vitamin D blood test is the main measure of vitamin D status. Vitamin D, 25-OH (https://medlineplus.gov/lab-tests/vitamin-d-test/)

Question for your doctor: My DNA report shows the VDR BsmI marker. Is a 25-hydroxy vitamin D blood test worth doing for me before I change the vitamin D I take?

Nutrients this finding is about: Vitamin D3

About these names: NIH notes that getting too much vitamin D can be harmful.

Read more: VDR gene, MedlinePlus Genetics (NIH), https://medlineplus.gov/genetics/gene/vdr/

Read more: Uitterlinden et al., 2004 (research review), PubMed (NIH), https://pubmed.ncbi.nlm.nih.gov/15315818/

Read more: Vitamin D fact sheet, NIH Office of Dietary Supplements, https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/

Where your result is the common version (3)

MTHFR A1298C (rs1801131), genotype AA, common version

Result: No copies of the A1298C variant.

Linked to: A1298C is the second of the two most-studied variants in MTHFR, the gene for the enzyme that turns folate into the form found in blood. This report links nothing further to this result.

What would tell you: Nothing further to measure for this result.

Question for your doctor: No question for your doctor from this result.

Read more: MTHFR gene, MedlinePlus Genetics (NIH), https://medlineplus.gov/genetics/gene/mthfr/

Read more: Weisberg et al., 1998 (research paper), PubMed (NIH), https://pubmed.ncbi.nlm.nih.gov/9719624/

Read more: Folate fact sheet, NIH Office of Dietary Supplements, https://ods.od.nih.gov/factsheets/Folate-HealthProfessional/

Read more: MTHFR and folic acid, CDC, https://www.cdc.gov/folic-acid/data-research/mthfr/index.html

APOE e2 marker (rs7412), genotype CC, common version

Result: No copies of e2.

Linked to: APOE makes a protein that packages cholesterol and other fats and carries them through the blood. This report links nothing further to this result.

What would tell you: Nothing further to measure for this result.

Question for your doctor: No question for your doctor from this result.

This page also covers health conditions the e4 form is linked to, not only fat transport.

Read more: APOE gene, MedlinePlus Genetics (NIH), https://medlineplus.gov/genetics/gene/apoe/

APOE e4 marker (rs429358), genotype TT, common version

Result: No copies of e4.

Linked to: APOE makes a protein that packages cholesterol and other fats and carries them through the blood. This report links nothing further to this result.

What would tell you: Nothing further to measure for this result.

Question for your doctor: No question for your doctor from this result.

This page also covers health conditions the e4 form is linked to, not only fat transport.

Read more: APOE gene, MedlinePlus Genetics (NIH), https://medlineplus.gov/genetics/gene/apoe/

What your findings are about

Methylfolate (5-MTHF)
Note: If you could become pregnant: NIH notes that the CDC's folic acid advice applies even with this variant, so ask your doctor before changing the form of folate you take.
Vitamin B12
B complex
Caffeine
Vitamin A (retinyl palmitate)
Note: If you are or might be pregnant or breastfeeding, NIH advises against large amounts of preformed vitamin A from supplements; ask your doctor first.
Vitamin D3

To see how any of these sits beside what you take, check it in Before you take it on canistackthis.com.

Genetic variants

MTHFR C677T (rs1801133), genotype CT: One copy of the C677T variant.

MTHFR A1298C (rs1801131), genotype AA: No copies of the A1298C variant.

CYP1A2 (rs762551), genotype CC: Two copies of the C version (CC).

COMT Val158Met (rs4680), genotype AA: Two copies of the Met version (AA).

APOE e2 marker (rs7412), genotype CC: No copies of e2.

APOE e4 marker (rs429358), genotype TT: No copies of e4.

FUT2 (rs602662), genotype GA: One copy of the A version (GA).

BCMO1 A379V (rs7501331), genotype CT: One copy of the 379V variant.

VDR BsmI (rs1544410), genotype TT: Two copies of the T version (TT).

This report is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Generated by CanIStackThis.com — your raw DNA file was processed in memory and never stored.

Your DNA report

Read from your file on 1 Aug 2026

Check these against my list

Folate (MTHFR)

somewhat lower activity

One copy of the C677T variant. The C677T variant makes this enzyme less active. The clearest link to higher homocysteine is in people with two copies, especially when folate status is low.

Vitamin B12 (FUT2)

one A copy

One copy of the A version (GA). In one large study, average B12 was higher in people with AA at this marker than in people with GA or GG; a group's average does not tell one person's level.

Caffeine (CYP1A2)

two C copies

Two copies of the C version (CC). In one study, people with CC broke caffeine down more slowly than people with AA, but only among smokers; among non-smokers the three results did not differ.

Vitamin D (VDR)

two T copies

Two copies of the T version (TT). BsmI is one of the most studied markers in this gene, but what it does to the receptor is largely unknown, and it is probably not functional itself.

Fat transport (APOE)

no e4

No copies of e4. This report links nothing further to this result.

Vitamin A from beta-carotene (BCMO1)

somewhat lower conversion

One copy of the 379V variant. In one study, people carrying the 379V variant turned beta-carotene into vitamin A less well.

Dopamine clearance (COMT)

two Met copies

Two copies of the Met version (AA). The Met version is linked to lower activity of this enzyme than the Val version, in studies of brain tissue.

🍽️ Foods for your genes

Everyday foods connected to the nutrients your results are about. A blood test, not a food list, is what shows a level.

Folate (MTHFR)

Fits this result: leafy greens (spinach, romaine), lentils & beans, asparagus, avocado, citrus

Folate is naturally present in many foods, especially dark green leafy vegetables, beans and asparagus. Folic acid is the form added to fortified foods and most supplements.

Vitamin A (beta-carotene conversion)

Fits this result: eggs, dairy, fish (preformed vitamin A sources)

Worth watching: relying on carrots and sweet potato alone for vitamin A

This result is linked to lower conversion of beta-carotene from plant foods into vitamin A. Preformed vitamin A, found in fish, dairy products and eggs, does not need that conversion. (If you are pregnant, vitamin A intake is a question for your clinician.)

Your findings

Your file has 6 results that differ from the common version: MTHFR C677T, CYP1A2 (rs762551), COMT Val158Met, FUT2 (rs602662), BCMO1 A379V (rs7501331) and VDR BsmI (rs1544410). The Findings tab says what each one is linked to and, where there is one, which blood test would tell you more and a question to bring to your doctor.

Check these against my list

These are what your findings are about. Checking one shows how it sits beside everything on your list, medicines included. It is not a suggestion to take it.

Methylfolate (5-MTHF)
If you could become pregnant: NIH notes that the CDC's folic acid advice applies even with this variant, so ask your doctor before changing the form of folate you take.
Vitamin B12
B complex
Caffeine
Vitamin A (retinyl palmitate)
If you are or might be pregnant or breastfeeding, NIH advises against large amounts of preformed vitamin A from supplements; ask your doctor first.
Vitamin D3

In your own report, each name here opens Before you take it, checked against the things on your list.

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All genotypes on this page are fictional and for illustration only. No real person's DNA was used. Reports are for educational purposes and are not a substitute for professional medical advice.