Supplement stacks / Hydrochlorothiazide + Licorice Root
Can You Take Hydrochlorothiazide with Licorice Root?
Hydrochlorothiazide and Licorice Root: one interaction flagged, scored 4/10 (medium risk). The count and score come from an AI-written analysis checked against our interaction rules, which can only make it stricter. Not medical advice.
Safety at a glance
Medium riskThis score comes from an AI-written analysis of the pair. Our interaction rules check it and can only make it stricter, never milder. Informational only: it can't account for your medications, conditions, or genetics.
What the AI-written analysis says
Combining hydrochlorothiazide with licorice root may pose risks due to potential interactions affecting blood pressure and electrolyte balance. Caution is advised.
Hydrochlorothiazide is a prescription medication. This page describes publicly documented interactions — it can't see your dose, your other prescriptions, or your labs. Discuss any supplement with the prescriber or pharmacist who manages this medication before combining.
Known interactions
Licorice root can lead to potassium loss and may counteract the effects of hydrochlorothiazide, increasing the risk of hypokalemia.
Hydrochlorothiazide
From the AI-written analysis.
Generally safe when used as prescribed, but may cause electrolyte imbalances.
Typical dosage: As prescribed or as directed on the label
- Dizziness
- Increased urination
- Low potassium levels
- Monitor blood pressure regularly
- Consult healthcare provider for electrolyte levels
Licorice Root
From the AI-written analysis.
May cause hypertension and hypokalemia, especially in high doses or prolonged use.
Typical dosage: 300 to 500 mg daily
- Headache
- High blood pressure
- Low potassium levels
- Avoid high doses
- Consult healthcare provider if on diuretics
Timing
No timing arrangement makes this combination safe — see the warnings above.
Watch out for
- Real licorice (not DGL), especially in large amounts, can lower potassium and raise blood pressure. Water pills such as hydrochlorothiazide, chlorthalidone, indapamide or furosemide (Lasix) lower potassium too, so together potassium can fall too low, which can cause muscle weakness or spasms, or an uneven heartbeat. Ask the prescriber or pharmacist before taking licorice with it, and do not stop or change the prescription on your own.
- Consult your healthcare provider before combining these substances to monitor for potential electrolyte imbalances.
Frequently asked questions
Can you take Hydrochlorothiazide and Licorice Root together?
Hydrochlorothiazide and Licorice Root: one interaction flagged, scored 4/10 (medium risk). The count and score come from an AI-written analysis checked against our interaction rules, which can only make it stricter. Not medical advice.
What score does the Hydrochlorothiazide and Licorice Root combination get?
The Hydrochlorothiazide and Licorice Root combination is scored 4/10 (medium risk). The score comes from an AI-written analysis checked against our interaction rules, which can only make it stricter. Not medical advice. Always confirm with a healthcare professional.
When should you take Hydrochlorothiazide and Licorice Root?
No timing arrangement makes this combination safe — see the warnings above.
What should you watch out for when combining Hydrochlorothiazide and Licorice Root?
Real licorice (not DGL), especially in large amounts, can lower potassium and raise blood pressure. Water pills such as hydrochlorothiazide, chlorthalidone, indapamide or furosemide (Lasix) lower potassium too, so together potassium can fall too low, which can cause muscle weakness or spasms, or an uneven heartbeat. Ask the prescriber or pharmacist before taking licorice with it, and do not stop or change the prescription on your own. Consult your healthcare provider before combining these substances to monitor for potential electrolyte imbalances.
Check your full list
Taking more than these two? Add everything you take, medicines included, to your list. We check each supplement on your list against the rest of it, and name anything we could not check. Free, and you don’t need an account.
Check my listWhat your DNA adds
Some genes in a raw 23andMe or AncestryDNA file are linked to how the body handles nutrients. The DNA report says what yours are linked to and, where there is one, which blood test would tell you more.
See the DNA reportRelated combinations
Not medical advice
This analysis is based on general supplement information. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult qualified healthcare providers before starting any supplement regimen.
AI-written analysis generated September 2, 2026, checked by our interaction rules · How our analysis works