Supplement stacks / Red Yeast Rice + Rosuvastatin
Can You Take Red Yeast Rice with Rosuvastatin?
Red Yeast Rice and Rosuvastatin: one interaction flagged, scored 3/10 (high risk). The count and score come from an AI-written analysis checked against our interaction rules, which can only make it stricter. Not medical advice.
Safety at a glance
This score comes from an AI-written analysis of the pair. Our interaction rules check it and can only make it stricter, never milder. Informational only: it can't account for your medications, conditions, or genetics.
What the AI-written analysis says
Combining red yeast rice with rosuvastatin may increase the risk of muscle-related side effects due to their similar mechanisms of action. Both substances can lower cholesterol levels, but the safety and efficacy of using them together have not been well-studied. Caution is advised, and consultation with a healthcare provider is essential before combining these two.
Rosuvastatin is a prescription medication. This page describes publicly documented interactions — it can't see your dose, your other prescriptions, or your labs. Discuss any supplement with the prescriber or pharmacist who manages this medication before combining.
Known interactions
Suggestion: Consult healthcare provider before use.
Red Yeast Rice
From the AI-written analysis.
Contains monacolin K, which is similar to lovastatin; may cause muscle pain and liver issues.
Typical dosage: 1200-2400 mg daily
- Muscle pain (1-10%)
- Digestive upset (1-10%)
- Headache (1-10%)
- Consult healthcare provider if experiencing muscle pain; monitor liver function.
Rosuvastatin
From the AI-written analysis.
Generally well-tolerated; however, may cause muscle pain, liver enzyme elevation, and gastrointestinal issues.
Typical dosage: As prescribed or as directed on the label
- Muscle pain (1-10%)
- Headache (1-10%)
- Nausea (1-10%)
- Monitor for muscle pain or weakness; liver function tests may be necessary.
- Avoid alcohol to reduce liver strain.
Also commonly mentioned
These come up in questions about this combination. They are not part of the pair above. From the AI-written analysis.
Coenzyme Q10
Generally safe; may help mitigate statin-related muscle pain.
Typical dosage: 100-300 mg daily
- Mild gastrointestinal upset (1-10%)
- Headache (1-10%)
- Consult healthcare provider if on blood thinners; may lower blood pressure.
Omega-3 Fatty Acids
Generally safe; may support cardiovascular health.
Typical dosage: 1000-4000 mg daily
- Fishy aftertaste (1-10%)
- Gastrointestinal discomfort (1-10%)
- Monitor for bleeding if on anticoagulants.
Vitamin D
Generally safe; supports overall health and may improve muscle function.
Typical dosage: 600-2000 IU daily
- Nausea (1-10%)
- Fatigue (1-10%)
- Monitor calcium levels if taking high doses.
Timing
No timing arrangement makes this combination safe — see the warnings above.
Recommendations
- Consult with a healthcare provider before combining red yeast rice with rosuvastatin.
- Consider Coenzyme Q10 to help mitigate potential muscle-related side effects.
Watch out for
- Red yeast rice contains a natural statin (monacolin K, the same compound as lovastatin), so taking it with a prescription statin is effectively a double dose and raises the risk of muscle damage (myopathy) and liver strain. Do not combine — watch for unexplained muscle pain or weakness, or dark urine, and talk to your prescriber.
- Monitor for muscle pain or weakness when taking red yeast rice with rosuvastatin; consult healthcare provider if symptoms occur.
Frequently asked questions
Can you take Red Yeast Rice and Rosuvastatin together?
Red Yeast Rice and Rosuvastatin: one interaction flagged, scored 3/10 (high risk). The count and score come from an AI-written analysis checked against our interaction rules, which can only make it stricter. Not medical advice.
What score does the Red Yeast Rice and Rosuvastatin combination get?
The Red Yeast Rice and Rosuvastatin combination is scored 3/10 (high risk). The score comes from an AI-written analysis checked against our interaction rules, which can only make it stricter. Not medical advice. Always confirm with a healthcare professional.
When should you take Red Yeast Rice and Rosuvastatin?
No timing arrangement makes this combination safe — see the warnings above.
What should you watch out for when combining Red Yeast Rice and Rosuvastatin?
Red yeast rice contains a natural statin (monacolin K, the same compound as lovastatin), so taking it with a prescription statin is effectively a double dose and raises the risk of muscle damage (myopathy) and liver strain. Do not combine — watch for unexplained muscle pain or weakness, or dark urine, and talk to your prescriber. Monitor for muscle pain or weakness when taking red yeast rice with rosuvastatin; consult healthcare provider if symptoms occur.
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Not medical advice
AI-written analysis generated August 11, 2026, checked by our interaction rules · How our analysis works