Supplement stacks / Omeprazole + Vitamin B12
Can You Take Omeprazole with Vitamin B12?
Omeprazole and Vitamin B12: one interaction flagged, scored 7/10 (medium risk). The count and score come from an AI-written analysis checked against our interaction rules, which can only make it stricter. Not medical advice.
Safety at a glance
This score comes from an AI-written analysis of the pair. Our interaction rules check it and can only make it stricter, never milder. Informational only: it can't account for your medications, conditions, or genetics.
What the AI-written analysis says
Omeprazole may affect the absorption of Vitamin B12, potentially leading to deficiency if used long-term. While taking Vitamin B12 with omeprazole is generally considered safe, monitoring levels may be advisable, especially with prolonged use. Vitamin B1 and other B vitamins are typically safe to take alongside omeprazole.
Omeprazole is a prescription medication. This page describes publicly documented interactions — it can't see your dose, your other prescriptions, or your labs. Discuss any supplement with the prescriber or pharmacist who manages this medication before combining.
Known interactions
Suggestion: Consider monitoring Vitamin B12 levels if using omeprazole long-term.
Omeprazole
From the AI-written analysis.
Generally safe; long-term use may lead to nutrient deficiencies.
Typical dosage: As prescribed or as directed on the label
- Headache
- Diarrhea
- Nausea
- Monitor for signs of nutrient deficiencies, especially B12.
Vitamin B12
From the AI-written analysis.
Generally safe; however, long-term use of omeprazole may impair absorption.
Typical dosage: 250-500 mcg daily
- Mild diarrhea
- Nausea
- Headache
- Monitor B12 levels if on omeprazole long-term.
- Consult healthcare provider if experiencing symptoms of deficiency.
Also commonly mentioned
These come up in questions about this combination. They are not part of the pair above. From the AI-written analysis.
Vitamin B1 (Thiamine)
Generally safe; no known significant interactions with omeprazole.
Typical dosage: 1.1-1.2 mg daily
- Rare allergic reactions
- Nausea
- Consult healthcare provider if on diuretics or have chronic conditions.
Vitamin B6 (Pyridoxine)
Generally safe; no known significant interactions with omeprazole.
Typical dosage: 1.3-2.0 mg daily
- Nausea
- Headache
- Fatigue
- High doses may lead to neuropathy; consult healthcare provider.
Folic Acid
Generally safe; no known significant interactions with omeprazole.
Typical dosage: 400-800 mcg daily
- Nausea
- Bloating
- Consult healthcare provider if on methotrexate or have kidney issues.
Timing
Take Vitamin B12 in the morning for optimal absorption, ideally on an empty stomach.
Recommendations
- Consider taking Vitamin B12 supplements if on omeprazole for an extended period.
- Consult with a healthcare provider for regular monitoring of Vitamin B12 levels.
Watch out for
- Monitor Vitamin B12 levels if using omeprazole long-term.
Frequently asked questions
Can you take Omeprazole and Vitamin B12 together?
Omeprazole and Vitamin B12: one interaction flagged, scored 7/10 (medium risk). The count and score come from an AI-written analysis checked against our interaction rules, which can only make it stricter. Not medical advice.
What score does the Omeprazole and Vitamin B12 combination get?
The Omeprazole and Vitamin B12 combination is scored 7/10 (medium risk). The score comes from an AI-written analysis checked against our interaction rules, which can only make it stricter. Not medical advice. Always confirm with a healthcare professional.
When should you take Omeprazole and Vitamin B12?
Take Vitamin B12 in the morning for optimal absorption, ideally on an empty stomach.
What should you watch out for when combining Omeprazole and Vitamin B12?
Monitor Vitamin B12 levels if using omeprazole long-term.
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Not medical advice
AI-written analysis generated August 10, 2026, checked by our interaction rules · How our analysis works