Supplement stacks / Metformin + Rapamycin (Sirolimus)
Can You Take Metformin with Rapamycin (Sirolimus)?
Metformin and Rapamycin (Sirolimus): no interactions flagged, scored 7/10 (medium risk). The count and score come from an AI-written analysis checked against our interaction rules, which can only make it stricter. Not medical advice.
Safety at a glance
This score comes from an AI-written analysis of the pair. Our interaction rules check it and can only make it stricter, never milder. Informational only: it can't account for your medications, conditions, or genetics.
What the AI-written analysis says
Metformin is a commonly prescribed medication for managing blood sugar levels in type 2 diabetes, while MK-677 (Ibutamoren) is a growth hormone secretagogue often used for muscle growth and fat loss. There are no direct interactions reported between metformin and MK-677, but caution is advised due to potential effects on glucose metabolism and the need for monitoring blood sugar levels.
Metformin is a prescription medication. This page describes publicly documented interactions — it can't see your dose, your other prescriptions, or your labs. Discuss any supplement with the prescriber or pharmacist who manages this medication before combining.
Rapamycin (Sirolimus) is a prescription medication. This page describes publicly documented interactions — it can't see your dose, your other prescriptions, or your labs. Discuss any supplement with the prescriber or pharmacist who manages this medication before combining.
Metformin
From the AI-written analysis.
Generally safe when prescribed; monitor for side effects, especially gastrointestinal issues and vitamin B12 deficiency.
Typical dosage: As prescribed or as directed on the label
- Nausea
- Diarrhea
- Abdominal discomfort
- Vitamin B12 deficiency (long-term use)
- Contraindicated in patients with severe kidney or liver disease; monitor renal function regularly.
Also commonly mentioned
These come up in questions about this combination. They are not part of the pair above. From the AI-written analysis.
MK-677 (Ibutamoren)
Generally considered safe for short-term use; long-term effects are not well-studied.
Typical dosage: As prescribed or as directed on the label
- Increased appetite
- Fatigue
- Edema
- Potential insulin resistance
- Monitor blood sugar levels, especially if diabetic; may affect glucose metabolism.
Timing
Take as prescribed — we do not schedule prescription medications. Follow the label or your prescriber, and ask your pharmacist before changing when you take it.
Watch out for
- Monitor blood sugar levels regularly while taking MK-677, as it may influence glucose metabolism.
Frequently asked questions
Can you take Metformin and Rapamycin (Sirolimus) together?
Metformin and Rapamycin (Sirolimus): no interactions flagged, scored 7/10 (medium risk). The count and score come from an AI-written analysis checked against our interaction rules, which can only make it stricter. Not medical advice.
What score does the Metformin and Rapamycin (Sirolimus) combination get?
The Metformin and Rapamycin (Sirolimus) combination is scored 7/10 (medium risk). The score comes from an AI-written analysis checked against our interaction rules, which can only make it stricter. Not medical advice. Always confirm with a healthcare professional.
When should you take Metformin and Rapamycin (Sirolimus)?
Take as prescribed — we do not schedule prescription medications. Follow the label or your prescriber, and ask your pharmacist before changing when you take it.
What should you watch out for when combining Metformin and Rapamycin (Sirolimus)?
Monitor blood sugar levels regularly while taking MK-677, as it may influence glucose metabolism.
Check your full stack
Taking more than these two? Add everything you take, medicines included, to your list. We check each supplement on your list against the rest of it, and name anything we could not check. Free, and you don’t need an account.
Analyze my stackWhat your DNA adds
Some genes in a raw 23andMe or AncestryDNA file are linked to how the body handles nutrients. The DNA report says what yours are linked to and, where there is one, which blood test would tell you more.
See the DNA reportRelated combinations
Not medical advice
AI-written analysis generated August 11, 2026, checked by our interaction rules · How our analysis works