Supplement stacks / Kava + Oxycodone
Can You Take Kava with Oxycodone?
Kava and Oxycodone: one interaction flagged, scored 3/10 (high risk). The count and score come from an AI-written analysis checked against our interaction rules, which can only make it stricter. Not medical advice.
Safety at a glance
This score comes from an AI-written analysis of the pair. Our interaction rules check it and can only make it stricter, never milder. Informational only: it can't account for your medications, conditions, or genetics.
What the AI-written analysis says
Combining kava with oxycodone poses significant risks due to potential additive sedative effects, which can lead to respiratory depression and increased sedation. Both substances can impair cognitive and motor functions, increasing the risk of accidents.
Oxycodone is a prescription medication. This page describes publicly documented interactions — it can't see your dose, your other prescriptions, or your labs. Discuss any supplement with the prescriber or pharmacist who manages this medication before combining.
Known interactions
Both oxycodone and kava are CNS depressants, which may lead to enhanced sedation and respiratory depression.
Kava
From the AI-written analysis.
May cause liver toxicity; use with caution, especially in individuals with liver conditions.
Typical dosage: 200-300 mg of kavalactones daily
- drowsiness
- gastrointestinal upset
- headache
- Avoid use with alcohol or other CNS depressants; consult healthcare provider if liver issues are present.
Oxycodone
From the AI-written analysis.
Use with caution; potential for addiction and respiratory depression. Monitor for signs of overdose.
Typical dosage: As prescribed or as directed on the label
- drowsiness
- constipation
- nausea
- dizziness
- Avoid combining with other CNS depressants; monitor for signs of respiratory depression.
- Consult healthcare provider before use.
Timing
No timing arrangement makes this combination safe — see the warnings above.
Recommendations
- Consult with a healthcare provider before combining kava with oxycodone.
- Consider alternative methods for managing anxiety or sleep that do not involve kava.
Watch out for
- Combining two or more central-nervous-system depressants can cause heavy sedation and badly impaired alertness, much more than either one alone. These include phenibut, kratom, kava, tianeptine, amanita (muscimol), blue lotus, benzodiazepines (e.g. Xanax), the sleep medicines zolpidem (Ambien), eszopiclone (Lunesta) and zaleplon (Sonata), gabapentin/pregabalin, opioids, sedating antidepressants such as trazodone and mirtazapine, sedating antipsychotics such as olanzapine and haloperidol, sedating antihistamines and anticholinergics such as promethazine, diphenhydramine and scopolamine, clonidine, and topiramate or zonisamide. With phenibut, kratom, kava, tianeptine, amanita or blue lotus, and with opioids, benzodiazepines, the sleep medicines above, or gabapentin and pregabalin, the combination can also cause dangerous, potentially fatal slowed breathing. The risk is much higher with alcohol. Ask a pharmacist, or the prescriber if any of these was prescribed, before you combine them. If any of these is a prescription, do not stop or change it on your own, because stopping some of these suddenly is dangerous in itself. Get emergency care for extreme drowsiness, confusion, or slow/shallow breathing.
- Do not combine kava with oxycodone due to the risk of severe sedation and respiratory depression.
Frequently asked questions
Can you take Kava and Oxycodone together?
Kava and Oxycodone: one interaction flagged, scored 3/10 (high risk). The count and score come from an AI-written analysis checked against our interaction rules, which can only make it stricter. Not medical advice.
What score does the Kava and Oxycodone combination get?
The Kava and Oxycodone combination is scored 3/10 (high risk). The score comes from an AI-written analysis checked against our interaction rules, which can only make it stricter. Not medical advice. Always confirm with a healthcare professional.
When should you take Kava and Oxycodone?
No timing arrangement makes this combination safe — see the warnings above.
What should you watch out for when combining Kava and Oxycodone?
Combining two or more central-nervous-system depressants can cause heavy sedation and badly impaired alertness, much more than either one alone. These include phenibut, kratom, kava, tianeptine, amanita (muscimol), blue lotus, benzodiazepines (e.g. Xanax), the sleep medicines zolpidem (Ambien), eszopiclone (Lunesta) and zaleplon (Sonata), gabapentin/pregabalin, opioids, sedating antidepressants such as trazodone and mirtazapine, sedating antipsychotics such as olanzapine and haloperidol, sedating antihistamines and anticholinergics such as promethazine, diphenhydramine and scopolamine, clonidine, and topiramate or zonisamide. With phenibut, kratom, kava, tianeptine, amanita or blue lotus, and with opioids, benzodiazepines, the sleep medicines above, or gabapentin and pregabalin, the combination can also cause dangerous, potentially fatal slowed breathing. The risk is much higher with alcohol. Ask a pharmacist, or the prescriber if any of these was prescribed, before you combine them. If any of these is a prescription, do not stop or change it on your own, because stopping some of these suddenly is dangerous in itself. Get emergency care for extreme drowsiness, confusion, or slow/shallow breathing. Do not combine kava with oxycodone due to the risk of severe sedation and respiratory depression.
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Not medical advice
AI-written analysis generated August 11, 2026, checked by our interaction rules · How our analysis works